Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Practical applications of atomic force microscopy in biomedicine
The last thirty years of progress of atomic force microscopy (AFM) applied to living matter is reviewed with a focus on potential uses in drug discovery or screening of patient samples.
Nicola Galvanetto
doaj +1 more source
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Carbon fibre tips for scanning probe microscopy based on quartz tuning fork force sensors
We report the fabrication and the characterization of carbon fibre tips for their use in combined scanning tunnelling and force microscopy based on piezoelectric quartz tuning fork force sensors.
A Castellanos-Gomez +13 more
core +1 more source
Extremely sharp carbon nanocone probes for atomic force microscopy imaging [PDF]
A simple and reliable catalyst patterning technique combined with electric-field-guided growth is utilized to synthesize a sharp and high-aspect-ratio carbon nanocone probe on a tipless cantilever for atomic force microscopy.
Chen, I-Chen +7 more
core +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Multifunctional hydrogel nano-probes for atomic force microscopy
Atomic force microscopy typically employs hard tips to map the surface topology of a sample, with sub-nanometre resolution. Here, the authors instead develop softer hydrogel probes, which show potential for multifunctional measurement capabilities beyond
Jae Seol Lee +8 more
doaj +1 more source
Array atomic force microscopy for real-time multiparametric analysis. [PDF]
Nanoscale multipoint structure-function analysis is essential for deciphering the complexity of multiscale biological and physical systems. Atomic force microscopy (AFM) allows nanoscale structure-function imaging in various operating environments and ...
Azam, Farooq +18 more
core +1 more source
Conduction of topologically-protected charged ferroelectric domain walls
We report on the observation of nanoscale conduction at ferroelectric domain walls in hexagonal HoMnO3 protected by the topology of multiferroic vortices using in situ conductive atomic force microscopy, piezoresponse force microscopy, and kelvin-probe ...
J. R. Guest +6 more
core +1 more source
Calculation of Intracellular Pressure of Red Blood Cells at Jaundice According to Atomic Force Microscopy Data [PDF]
The present work is devoted to the analysis of three-dimensional data of atomic force microscopy for research of the morphology of red blood cells.
Nagornov, Yu.S., Zhilyaev, I.V
core +1 more source

