Results 41 to 50 of about 1,591,330 (250)

VTA monosynaptic connections by local glutamate and GABA neurons and their distinct roles in behavior

Nature Communications
The ventral tegmental area (VTA) dopamine neurons have been implicated in diverse behaviors. These VTAdopamine neurons are intermixed with neurons that co-transmit glutamate and GABA (VTAglutamate-GABA), transmit glutamate (VTAglutamate-only) or GABA ...
M. Flavia Barbano, Huiling Wang, Shiliang Zhang, Alexey V. Shevelkin, Kevin J. Yu, Christopher T. Richie, Bing Liu, Suyun Hahn, Rong Ye, Marisela Morales   +9 more
doaj   +1 more source

Laser Treatment Monitoring with Reflectance Confocal Microscopy

Medicina, 2023
Laser treatments have become popular in Dermatology. In parallel to technologic development enabling the availability of different laser wavelengths, non-invasive skin imaging techniques, such as reflectance confocal microscopy (RCM), have been used to ...
Stefania Guida, Caterina Longo, Simone Amato, Anthony M. Rossi, Marco Manfredini, Silvana Ciardo, Marco Spadafora, Steven P. Nisticò, Santo R. Mercuri, Franco Rongioletti, Nicola Zerbinati, Giovanni Pellacani   +11 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Label-free 3D visualization of cellular and tissue structures in intact muscle with second and third harmonic generation microscopy. [PDF]

, 2011
Second and Third Harmonic Generation (SHG and THG) microscopy is based on optical effects which are induced by specific inherent physical properties of a specimen.
Krombach Fritz, Rehberg, Markus, Fritz Krombach, Steffen Dietzel, Rehberg Markus, Pohl Ulrich, Dietzel, Steffen, Dietzel Steffen, Markus Rehberg, Ulrich Pohl, Pohl, Ulrich, Krombach, Fritz   +11 more
core   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Confocal laser scanning microscopy of nanoparticles applied to immunosorbent assays [PDF]

, 2011
The aim of this project was to demonstrate and develop a confocal readout method for fluorescent immunosorbent assays and investigate its potential advantages in comparison to traditional immunoassays.
Ghafari, H
core  

Towards many colors in FISH on 3D-preserved interphase nuclei [PDF]

, 2006
The article reviews the existing methods of multicolor FISH on nuclear targets, first of all, interphase chromosomes. FISH proper and image acquisition are considered as two related components of a single process.
Müller, Stefan, Speicher, Michael R., Benecletti, P. A., Solovei, Irina, Cremer, T., Joffe, B., Albiez, H., Cremer, M., Walter, J., Bolzer, A., Walter, J.;Joffe, B.;Bolzer, A.;Albiez, H.;Benedetti, P. A.;Müller, S.;Speicher, M. R.;Cremer, T.;Cremer, M.;Solovei, I.   +10 more
core   +1 more source

Morphological and molecular characterization of Paratylenchus beltsvillensis n. sp. (Tylenchida: Paratylenchidae) from the rhizosphere of pine tree (Pinus virginiana Mill) in Maryland, USA [PDF]

Journal of Nematology, 2021
Mihail R. Kantor, Zafar A. Handoo, Sergei A. Subbotin, Gary R. Bauchan, Joseph D. Mowery   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source