Results 91 to 100 of about 160,406 (282)

Bioorthogonal Photoactivation of 2‐Nitrobenzyl Caged Doxorubicin Anticancer Prodrugs on Gold Nanostars

Advanced Materials, EarlyView.
Bioorthogonal chemistry was applied to intracellularly photoactivate Doxorubicin (Dox) using gold nanostars (AuNSt) and near‐infrared (NIR) light. Two prodrugs were used: one photoactivatable, masked with 2‐nitrobenzyl carbamate (proDox1) and another photolabile, masked with 2‐nitrobenzyl diol (proDox2), which was attached to the AuNSt surface.
Juan José Esteve‐Moreno, Andrea Escudero, Oscar Ferreira Silvestre, José Manuel Terrés, Mónica Gorbe, Eva Garrido, Carlos Renero‐Lecuna, Judith Langer, María Alfonso, Javier Ibañez, Félix Sancenón, Roberto Cao‐Milán, Luis M. Liz‐Marzán, Alba García‐Fernández, Andy Hernández‐Montoto, Ramón Martínez‐Máñez   +15 more
wiley   +1 more source

Large-depth three-photon fluorescence microscopy imaging of cortical microvasculature on nonhuman primates with bright AIE probe In vivo.

Biomaterials, 2022
Multiphoton microscopy has been a powerful tool in brain research, three-photon fluorescence microscopy is increasingly becoming an emerging technique for neurological research of the cortex in depth.
Hequn Zhang, Peng Fu, Yin Liu, Zheng Zheng, Liang Zhu, Mengqi Wang, M. Abdellah, Mubin He, Jun Qian, A. Roe, Wang Xi   +10 more
semanticscholar   +1 more source

Two-photon microscopy : sequential imaging studies in vivo [PDF]

, 2011
Microscopists have always desired to look inside various organ tissues to study structure, function and dysfunction of their cellular constituents. In the past, this has frequently required tissue extraction and histological preparation to gain access ...
Zammit, Christian, Di Giovanni, Giuseppe, Pierucci, Massimo, Muscat, Richard, Valentino, Mario   +4 more
core  

Automated analysis of spine dynamics on live CA1 pyramidal cells [PDF]

, 2015
Dendritic spines may be tiny in volume, but are of major importance for neuroscience. They are the main receivers for excitatory synaptic connections, and their constant changes in number and in shape reflect the dynamic connectivity of the brain.
Vetter, Thomas, Oertner, Thomas G., Genoud, Christel, Blumer, Clemens, Perez-Alvarez, Alberto, Vivien, Cyprien, Wiegert, J. Simon   +6 more
core   +1 more source

Whole brain functional recordings at cellular resolution in zebrafish larvae with 3D scanning multiphoton microscopy

Scientific Reports, 2021
Optical recordings of neuronal activity at cellular resolution represent an invaluable tool to investigate brain mechanisms. Zebrafish larvae is one of the few model organisms where, using fluorescence-based reporters of the cell activity, it is possible
M. Bruzzone, E. Chiarello, M. Albanesi, M. E. Miletto Petrazzini, A. Megighian, Claudia Lodovichi, M. dal Maschio   +6 more
semanticscholar   +1 more source

Harnessing Ultrafast Optical Pulses for 3D Microfabrication by Selective Tweezing and Immobilization of Colloidal Particles in an Integrated System

Advanced Photonics Research, Volume 6, Issue 5, May 2025.
Microfabrication using nano‐ to micron‐sized blocks has transformative potential for next‐gen electronics, optoelectronics, and materials. Traditional methods are limited by scalability and precision. STIC, a single‐laser system for precise colloid manipulation and immobilization using femtosecond lasers, is introduced that enables efficient 3D ...
Krishangi Krishna, Jieliyue Sun, Wenyu Liu, Robert H. Hurt, Kimani C. Toussaint Jr.   +4 more
wiley   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Spatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber

Scientific Reports, 2021
Beam self-cleaning (BSC) in graded-index (GRIN) multimode fibers (MMFs) has been recently reported by different research groups. Driven by the interplay between Kerr effect and beam self-imaging, BSC counteracts random mode coupling, and forces laser ...
Nawell Ould Moussa, Tigran Mansuryan, Charles-Henri Hage, Marc Fabert, Katarzyna Krupa, Alessandro Tonello, Mario Ferraro, Luca Leggio, Mario Zitelli, Fabio Mangini, Alioune Niang, Guy Millot, Massimiliano Papi, Stefan Wabnitz, Vincent Couderc   +14 more
doaj   +1 more source

Multi messenger multiphoton microscopy (Conference Presentation)

, 2019
Multiphoton microscopy was more than a revolution in optical microscopy and more in general in optical bioimaging. In the last 25 years has enabled unprecedented exploration of biological systems including living organisms.
Diaspro, Alberto
core   +1 more source

Multiphoton fluorescence lifetime imaging of human hair

, 2022
S.154-161In vivo and in vitro multiphoton imaging was used to perform high resolution optical sectioning of human hair by nonlinear excitation of endogenous as well as exogenous fluorophores. Multiphoton fluorescence lifetime imaging (FLIM) based on time-
Ehlers, A., Stark, M., Riemann, I., König, K.   +3 more
core   +1 more source