Results 101 to 110 of about 160,406 (282)

Imaging the Deep Spinal Cord Microvascular Structure and Function with High‐Speed NIR‐II Fluorescence Microscopy

Small Methods, 2022
The spinal cord (SC) is crucial for a myriad of somatosensory, autonomic signal processing, and transductions. Understanding the SC vascular structure and function thus plays an integral part in neuroscience and clinical research.
Hequn Zhang, Liang Zhu, Dave Schwinn Gao, Yin Liu, Jun Zhang, Min Yan, Jun Qian, Wang Xi   +7 more
semanticscholar   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Label-free rat brain traumatic penumbra imaging based on multiphoton fluorescence microscopy

Journal of Innovative Optical Health Sciences
Traumatic penumbra (TP) is a region with recoverable potential around the primary lesion of brain injury. Rapid and accurate imaging for identifying TP is essential for treating traumatic brain injury (TBI).
Shanghai Jiang, Pan Guo, Li Ai, Yuancan Li, Le Chen, Jie Zhong, Hua Yang, Hong Lu   +7 more
doaj   +1 more source

In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy

Acta Neuropathologica Communications, 2019
Summary The detection of amyloid beta deposits and neurofibrillary tangles, both hallmarks of Alzheimer’s disease (AD), is key to understanding the mechanisms underlying these pathologies. Luminescent conjugated oligothiophenes (LCOs) enable fluorescence
Maria Calvo-Rodriguez, Steven S. Hou, Austin C. Snyder, Simon Dujardin, Hamid Shirani, K. Peter R. Nilsson, Brian J. Bacskai   +6 more
doaj   +1 more source

MONTE CARLO SIMULATION OF MULTIFOCAL STOCHASTIC SCANNING SYSTEM [PDF]

Journal of Innovative Optical Health Sciences, 2014
Multifocal multiphoton microscopy (MMM) has greatly improved the utilization of excitation light and imaging speed due to parallel multiphoton excitation of the samples and simultaneous detection of the signals, which allows it to perform three ...
LIXIN LIU, JIA QIAN, YAHUI LI, XIAO PENG, JUN YIN   +4 more
doaj   +1 more source

In-vivo observation of cells with a combined high-resolution multiphoton-acoustic scanning microscope

, 2022
S.476-480We present a combined multiphoton-acoustic microscope giving collocated access to the local morphological as well as mechanical properties of living cells.
Lemor, R.M., Stracke, F., Schenkl, S., Stark, M., Weiss, E.C., Sauer, D., Riemann, I., König, K.   +7 more
core   +1 more source

Extreme Polaritonic Interactions in a Room‐Temperature Designable Sub‐Nanocavity Quantum Electrodynamic Platform

Advanced Science, EarlyView.
 A nanoparticle‐cluster‐on‐mirror (NPcoM) serves as a functionally deterministic sub‐nanocavity that emulates picocavities, enabling extreme light–matter interactions and polaritonic phenomena. ABSTRACT Pushing nanoscale optical confinement to its ultimate limits defines the regime of nano‐cavity quantum electrodynamics (nano‐cQED), where light‐matter ...
Huatian Hu, Xin Shu, Zhiwei Hu, Di Zheng, Ruiqian Zhang, Ximin Cui, Wei Dai, Xiang Lan, Xiaobo Han, Wen Chen, Hongxing Xu   +10 more
wiley   +1 more source

Development of an intravital imaging system for the synovial tissue reveals the dynamics of CTLA-4 Ig in vivo

Scientific Reports, 2020
There have been many attempts to visualize the inflamed joints using multiphoton microscopy. However, due to the hypervascular and multilayered structure of the inflamed synovium, intravital imaging of the deep synovial tissue has been difficult.
Tetsuo Hasegawa, Junichi Kikuta, Takao Sudo, Erika Yamashita, Shigeto Seno, Tsutomu Takeuchi, Masaru Ishii   +6 more
doaj   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

A phasor approach analysis of multiphoton FLIM measurements of three-dimensional cell culture models

, 2022
Paper 97120XFluorescence lifetime imaging microscopy (FLIM) is a useful approach to obtain information regarding the endogenous fluorophores present in biological samples.
Schenke-Layland, Katja, Lakner, Pirmin, Brucker, Sara Y., Möller, Yvonne, Monaghan, Michael G., Olayioye, Monilola A.   +5 more
core   +1 more source