Results 31 to 40 of about 1,467,330 (258)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Label-Free Non-linear Multimodal Optical Microscopy—Basics, Development, and Applications

Frontiers in Physics, 2019
Non-linear optical (NLO) microscopy has proven to be a powerful tool especially for tissue imaging with sub-cellular resolution, high penetration depth, endogenous contrast specificity, pinhole-less optical sectioning capability.
Nirmal Mazumder, Naveen K. Balla, Guan-Yu Zhuo, Guan-Yu Zhuo, Yury V. Kistenev, Yury V. Kistenev, Rajesh Kumar, Fu-Jen Kao, Sophie Brasselet, Viktor V. Nikolaev, Viktor V. Nikolaev, Natalya A. Krivova   +11 more
doaj   +1 more source

Ptychographic lens-less birefringence microscopy using a mask-modulated polarization image sensor

Scientific Reports, 2023
Birefringence, an inherent characteristic of optically anisotropic materials, is widely utilized in various imaging applications ranging from material characterizations to clinical diagnosis.
Jeongsoo Kim, Seungri Song, Hongseong Kim, Bora Kim, Mirae Park, Seung Jae Oh, Daesuk Kim, Barry Cense, Yong-min Huh, Joo Yong Lee, Chulmin Joo   +10 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy. [PDF]

, 2015
Despite the great progress recently made in resolving their structures, investigation of the structural biology of membrane proteins still presents major challenges.
Shaun Rawson, Mitchell, JK, Postis, Vincent; id_orcid, Vincent Postis, Tim R Dafforn, Postis, Vincent, Muench, Stephen P., Baldwin, SA, Rawson, Shaun, Baldwin, Stephen A., Postis, V, Rawson, S, Stephen A Baldwin, Lee, SC, Rosemary A Parslow, Mitchell, Jennifer K., Dafforn, TR, Lee, Sarah C., Parslow, Rosemary A., Jennifer K Mitchell, Sarah C Lee, Stephen P Muench, Muench, SP, Dafforn, Tim R., Parslow, RA   +24 more
core   +1 more source

Spin polarization asymmetry at the surface of chromia

New Journal of Physics, 2014
We demonstrate boundary spin polarization at the surface of a Cr _2 O _3 single crystal using spin-polarized low-energy electron microscopy (SPLEEM), complementing prior spin polarized photoemission, spin polarized inverse photoemission, and x-ray ...
Shi Cao, Xin Zhang, Ning Wu, A T N’Diaye, G Chen, A K Schmid, Xumin Chen, W Echtenkamp, A Enders, Ch Binek, P A Dowben   +10 more
doaj   +1 more source

Physical Origins of Extreme Cross-Polarization Extinction in Confocal Microscopy

Physical Review X, 2021
Confocal microscopy is an essential imaging tool for biological systems, solid-state physics and nanophotonics. Using confocal microscopes allows performing resonant fluorescence experiments, where the emitted light has the same wavelength as the ...
Meryem Benelajla, Elena Kammann, Bernhard Urbaszek, Khaled Karrai   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

OOPS: Object-Oriented Polarization Software for analysis of fluorescence polarization microscopy images.

PLoS Computational Biology
Most essential cellular functions are performed by proteins assembled into larger complexes. Fluorescence Polarization Microscopy (FPM) is a powerful technique that goes beyond traditional imaging methods by allowing researchers to measure not only the ...
William F Dean, Tomasz J Nawara, Rose M Albert, Alexa L Mattheyses   +3 more
doaj   +1 more source

Longitudinal strain of epitaxial graphene monolayers on SiC substrates evaluated by z-polarization Raman microscopy

AIP Advances, 2019
Longitudinal strains in epitaxial monolayer graphene (EMG) grown on SiC substrates were evaluated by z-polarization Raman microscopy. Due to the covalent bonds formed at the interface between graphene and the substrate, strong compressive strains were ...
Yuika Saito, Kenshiro Tokiwa, Takahiro Kondo, Jianfeng Bao, Tomo-o Terasawa, Wataru Norimatsu, Michiko Kusunoki   +6 more
doaj   +1 more source