Results 171 to 180 of about 2,802,077 (293)

Two-Photon Fluorescence and Second-Harmonic Generation Microscopy: Principles and Biomedical Applications. [PDF]

J Biophotonics
Makkithaya KN, Raju G, Das S, Patil A, Kumar R, Kistenev YV, Zhuo GY, Mazumder N.   +7 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

White matter fiber bundles enable robust conduction and time-critical signaling despite axon caliber variation. [PDF]

Commun Biol
Mordhorst L, Weiskopf N, Morawski M, Mohammadi S.   +3 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Partial coherence of inelastically scattered electrons in transmission electron microscopy. [PDF]

Microscopy (Oxf)
Mendis BG.
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Evaluation of six different tests for Schistosoma haematobium diagnosis in a near-elimination setting: A prospective observational diagnostic accuracy study. [PDF]

PLoS Negl Trop Dis
Ndum NC, Ali SM, Ali MN, Bergelin J, Hattendorf J, Hoekstra PT, van Lieshout L, Pennance T, Suleiman KR, Utzinger J, Ward P, Webster BL, Knopp S.   +12 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Longitudinal live-cell chemical imaging using coherent Raman scattering microscopy.

Analyst
Zhang C, Ma S, Zhou M, Lukov LL, Zafarjafarzadeh N.   +4 more
europepmc   +1 more source

Antibacterial activity and biofilm inhibition of a novel bioactive glass coating (F18) on titanium discs. [PDF]

Braz Dent J
Balderrama ÍF, Nascimento KBD, Souza CWO, Souza MT, Zanotto ED, Marcantonio E.   +5 more
europepmc   +1 more source