The precise structures and stereochemistry of trihydroxy-linoleates esterified in human and porcine epidermis and their significance in skin barrier function: Implication of an epoxide hydrolase in the transformations of linoleate [PDF]
, 2016 Creation of an intact skin water barrier, a prerequisite for life on dry land, requires the lipoxygenase-catalyzed oxidation of the essential fatty acid linoleate, which is esterified to the ω-hydroxyl of an epidermis-specific ceramide.
Boeglin, William E. +5 more
core +1 more source
Advanced Science, Volume 11, Issue 24, June 26, 2024.A novel cell membrane coating is designed by hybridizing the membranes from platelets and chemokine receptor 2 overexpressing cells to cross the blood brain barrier (BBB) and target neuroinflammatory lesions. Rapamycin and 1‐trifluoromethoxyphenyl‐3‐(1‐propionylpiperidin‐4‐yl) urea (TPPU) are loaded into the liposomes to achieve a synergistic therapy ...
Rong‐Rong Lin +9 more
wiley +1 more source
Novel Pathways Of Ponatinib Disposition Catalysed By CYP1A1 Involving Generation Of Potentially Toxic Metabolites [PDF]
, 2017 Ponatinib, a pan-BCR-ABL tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia (CML), causes severe side-effects including vascular occlusions, pancreatitis and liver toxicity, although the underlying mechanisms remain unclear ...
Boerma +13 more
core +2 more sources
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension [PDF]
, 2016 Metabolic pathways enriched with genes differentially expressed in ISIAH and WAG renal medulla.
Arcady L. Markel +5 more
core +6 more sources
Chemical Proteomics Reveals Soluble Epoxide Hydrolase as a Therapeutic Target for Ocular Neovascularization [PDF]
, 2018 The standard-of-care therapeutics for the treatment of ocular neovascular diseases like wet age-related macular degeneration (AMD) are biologics targeting vascular endothelial growth factor signaling.
Boulton, Michael E. +13 more
core +1 more source
Regulation of cardiovascular biology by microsomal epoxide hydrolase. [PDF]
Toxicol Res, 2021 Edin ML, Zeldin DC.
europepmc +1 more source
Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study [PDF]
, 2016 BACKGROUND: Traffic exhaust, refineries and industrial facilities are major sources of air toxics identified by the U.S. Environmental Protection Agency (U.S. EPA) for their potential risk to human health.
Dejian Lai +5 more
core +2 more sources
Neurobehavioural changes and persistence of complaints in workers exposed to styrene in a polyester boat building plant: influence of exposure characteristics and microsomal epoxide hydrolase phenotype [PDF]
, 2001 Mineke Viaene +4 more
openalex +1 more source
Differential Induction of Microsomal and Soluble Epoxide Hydrolases by Arsenic in Drinking Water [PDF]
, 2023 Hui Li +5 more
openalex +1 more source