Results 11 to 20 of about 2,725 (177)

Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H1.2. Association with Sodium-Dependent Bile Acid Transport. [PDF]

PLoS ONE, 2015
Microsomal epoxide hydrolase (mEH) is a bifunctional protein that plays a central role in the metabolism of numerous xenobiotics as well as mediating the sodium-dependent transport of bile acids into hepatocytes.
Hui Peng, Qin-shi Zhu, Shuping Zhong, Daniel Levy   +3 more
doaj   +2 more sources

Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A. [PDF]

J Autoimmun, 2007
Autoimmune responses were observed in a large proportion of hepatitis C cases and are suspected to be part of viral pathogenesis. The AN6520 antigen (AN-Ag) is a normal cellular protein mainly expressed in liver that was found associated with non-A, non-B hepatitis.
Akatsuka T, Kobayashi N, Ishikawa T, Saito T, Shindo M, Yamauchi M, Kurokohchi K, Miyazawa H, Duan H, Matsunaga T, Komoda T, Morisseau C, Hammock BD.   +12 more
europepmc   +4 more sources

Microsomal Epoxide Hydrolase Polymorphism and Risk of Spontaneous Abortion

Epidemiology, 1998
We conducted a nested case-control study to examine the association of microsomal epoxide hydrolase polymorphism with spontaneous abortion. The analysis included 127 cases and 107 controls from a rural community in China. The prevalence of the homozygous wild-type (AA), the heterozygous variant (Aa), and the homozygous variant (aa) in exon 3 of epoxide
Xiaobin Wang, Ming Wang, Tianhua Niu, Changzhong Chen, Xiping Xu   +4 more
openalex   +4 more sources

Association of microsomal epoxide hydrolase polymorphisms and lung cancer risk [PDF]

British Journal of Cancer, 2003
Microsomal epoxide hydrolase (mEH) plays a dual role in the detoxification and activation of tobacco procarcinogens. Two polymorphisms affecting enzyme activity have been described in the exons 3 and 4 of the mEH gene, which result in the substitution of amino acids histidine to tyrosine at residue 113, and arginine to histidine at residue 139 ...
Andrea Gsur, Thomas Zidek, K Schnattinger, Elisabeth Feik, Gerald Haidinger, Peter Hollaus, Andrea Mohn-Staudner, C Armbruster, Stephan Madersbacher, Georg Schatzl, Klemens Trieb, Christian Vutuc, M. Micksche   +12 more
openalex   +3 more sources

Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. [PDF]

Insect Biochem Mol Biol, 2013
Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD.   +6 more
europepmc   +3 more sources

Monoclonal antibodies reveal multiple forms of expression of human microsomal epoxide hydrolase. [PDF]

Toxicol Appl Pharmacol, 2012
Duan H, Takagi A, Kayano H, Koyama I, Morisseau C, Hammock BD, Akatsuka T.   +6 more
europepmc   +3 more sources

Strategies for the Immobilization and Signal Amplification of a Double Nanobody Sandwich ELISA for Human Microsomal Epoxide Hydrolase. [PDF]

Anal Chem
He Q, Pan B, McCoy M, Pan J, Xu Z, Morisseau C, Sun G, Li D, Hammock BD.   +8 more
europepmc   +2 more sources

Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling. [PDF]

Toxicol Appl Pharmacol, 2012
Bhattacharya P, Sen N, Hoyer PB, Keating AF.   +3 more
europepmc   +3 more sources

The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter. [PDF]

J Pharmacol Exp Ther, 2009
Yang X, Liang SH, Weyant DM, Lazarus P, Gallagher CJ, Omiecinski CJ.   +5 more
europepmc   +3 more sources

5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1/sEH inhibitors as promising anticancer candidates. [PDF]

Arch Pharm (Weinheim)
5‐Methyl‐2‐carboxamidepyrrole‐based compounds were disclosed as new microsomal prostaglandin E2 synthase‐1 (mPGES‐1)/soluble epoxide hydrolase (sEH) inhibitors, highlighting their promising profile as anticancer agents. A combined in silico/experimental approach is reported, highlighting its applicability for discovering novel bioactive compounds ...
Colarusso E, Lauro G, Potenza M, Galatello P, Garigliota MLD, Ferraro MG, Piccolo M, Chini MG, Irace C, Campiglia P, Hoffstetter RK, Werz O, Ramunno A, Bifulco G.   +13 more
europepmc   +2 more sources