Results 11 to 20 of about 6,917 (192)

Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients. [PDF]

PLoS ONE, 2015
AimThe present study aimed to evaluate the effects of gene variants in key genes influencing pharmacokinetic and pharmacodynamic of carbamazepine (CBZ) on the response in patients with epilepsy.Materials & methodsFive SNPs in two candidate genes ...
Armond Daci, Giangiacomo Beretta, Driton Vllasaliu, Aida Shala, Valbona Govori, Giuseppe Danilo Norata, Shaip Krasniqi   +6 more
doaj   +25 more sources

Deletion of microsomal epoxide hydrolase gene leads to increased density in cerebral vasculature and enhances cerebral blood flow in mice. [PDF]

J Cereb Blood Flow Metab
Marowsky A, Wyss MT, Kindler D, Khalid NU, Rudin M, Weber B, Arand M.   +6 more
europepmc   +3 more sources

Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. [PDF]

Insect Biochem Mol Biol, 2013
Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD.   +6 more
europepmc   +3 more sources

Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter. [PDF]

Gene, 2014
Su S, Omiecinski CJ.
europepmc   +2 more sources

EPHX1 enhances drug resistance to regorafenib by activating the JAK/STAT signaling pathway in hepatocellular carcinoma cell lines [PDF]

Hereditas
Background Regorafenib serves as a second-line treatment for patients with advanced hepatocellular carcinoma (HCC). Microsomal epoxide hydrolase 1 (EPHX1) is closely associated with tumorigenesis and drug resistance.
Bin Xu, Xiangnan Liang, Wuguang Liu, BaiTong Wu, Qiuxiang Wang, Gong Kai, Chun Han, Binwen Sun, Bing Dong, Chengyong Dong, Liming Wang   +10 more
doaj   +2 more sources

Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease. [PDF]

Gene, 2015
Václavíková R, Hughes DJ, Souček P.
europepmc   +2 more sources

Development of potent inhibitors of the human microsomal epoxide hydrolase. [PDF]

Eur J Med Chem, 2020
Barnych B, Singh N, Negrel S, Zhang Y, Magis D, Roux C, Hua X, Ding Z, Morisseau C, Tantillo DJ, Siegel JB, Hammock BD.   +11 more
europepmc   +3 more sources

Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling. [PDF]

Toxicol Appl Pharmacol, 2012
Bhattacharya P, Sen N, Hoyer PB, Keating AF.   +3 more
europepmc   +3 more sources

Hepatitis B spliced protein (HBSP) promotes the carcinogenic effects of benzo [alpha] pyrene by interacting with microsomal epoxide hydrolase and enhancing its hydrolysis activity. [PDF]

BMC Cancer, 2014
Chen JY, Chen WN, Jiao BY, Lin WS, Wu YL, Liu LL, Lin X.   +6 more
europepmc   +3 more sources

Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis. [PDF]

Arch Insect Biochem Physiol, 2013
Kamita SG, Oshita GH, Wang P, Morisseau C, Hammock BD, Nandety RS, Falk BW.   +6 more
europepmc   +3 more sources