Results 51 to 60 of about 6,917 (192)

Long‐term treatment with carbamazepine restores cognitive abilities in a mouse model of KCNQ2 developmental and epileptic encephalopathy

Epilepsia Open, Volume 10, Issue 4, Page 1199-1207, August 2025.
Abstract Objective Carbamazepine is the first line treatment for patients affected by KCNQ2 developmental and epileptic encephalopathy. It is efficient to reduce or stop seizures in this context. However, its effect on the neurodevelopmental outcomes is debated.
Jordane Louis, Natalia Doudka, Marie‐Solenne Félix, Adeline Spiga Ghata, Camille Espanet, Romain Guilhaumou, Mathieu Milh, Laurent Villard   +7 more
wiley   +1 more source

Detoxification Strategy of Epoxide Hydrolase [PDF]

, 2003
The human microsomal epoxide hydrolase, a single enzyme, has to detoxify a broad range of structurally diverse, potentially genotoxic epoxides that are formed in the course of xenobiotic metabolism. The enzyme has developed a unique strategy to combine a
Arand, Michael, Cronin, Annette, Hengstler, Jan G., Herrero Plana, Maria Elena, Lohmann, Matthias, Oesch, Franz   +5 more
core  

Genetic susceptibility. [PDF]

, 2014
Why only 20% of smokers develop clinically relevant chronic obstructive pulmonary disease (COPD) was a puzzle for many years. Now, epidemiologic studies point clearly toward a large heritable component.
Lomas, David A, Marciniak, Stefan J
core   +1 more source

Regulation of P450-derived epoxy fatty acids in cardiovascular diseases

Redox Biochemistry and Chemistry
The cytochrome P450 (P450 or CYP) superfamily, while extensively recognized for xenobiotic metabolism, is also critically involved in the biosynthesis of lipid mediators from polyunsaturated fatty acids (PUFAs).
Matthew L. Edin, Joan P. Graves, Darryl C. Zeldin   +2 more
doaj   +1 more source

Unveiling New Triazoloquinoxaline‐Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9

Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.
We present new BRD9‐targeting degraders featuring a chemical warhead and E3 ligase ligand that distinctly differ from the typical chemical units used for BRD9 degradation. Specifically, we identified two VHL‐based PROTACs (2 and 9) based on a [1,2,4]triazolo[4,3‐a]quinoxaline scaffold that effectively and selectively degrade BRD9 and exhibit ...
Martina Pierri, Guglielmo Bove, Erica Gazzillo, Ester Colarusso, Francesca Scala, Giacomo Pepe, Stefania Terracciano, Maria Giovanna Chini, Nicla Simonelli, Ines Bruno, Angela Nebbioso, Pietro Campiglia, Giuseppe Bifulco, Lucia Altucci, Nunzio Del Gaudio, Gianluigi Lauro   +15 more
wiley   +1 more source

Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. [PDF]

, 2017
Epoxides are highly useful synthons and biosynthons for the construction of complex natural products during total synthesis and biosynthesis, respectively.
Garcia-Borràs, Marc, Hirayama, Yuichiro, Houk, KN, Li, Dehai H, Li, Li, Tang, Mancheng C, Tang, Yi, Watanabe, Kenji, Zou, Yi   +8 more
core  

Gene evolution of epoxide hydrolases and recommended nomenclature [PDF]

, 1995
We have analyzed amino acid sequence relationships among soluble and microsomal epoxide hydrolases, haloacid dehalogenases, and a haloalkane dehalogenase.
Arand, Michael, Beetham, J K, Belknap, W R, Garbarino, J, Grant, D, Hammock, B D, Kiyosue, T, Oesch, F, Pinot, F, Shinozaki, K   +9 more
core   +1 more source

Reversible Neonatal Cholestasis Following In Utero Exposure to Valproic Acid

McGill Journal of Medicine, 2020
Valproic acid (VPA) is a branched-chain carboxylic acid with broad anticonvulsant activity. Its spectrum of activity is thought to be mediated by combined molecular effects on intercellular Na+ currents, neuron K+ channels, and inhibition of gamma ...
Douglas G Chang, Martin Stein, David Sine, David Yeung, Frank Mannino   +4 more
doaj   +1 more source

Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. [PDF]

, 2008
Individuals with Lynch syndrome are predisposed to cancer due to an inherited DNA mismatch repair gene mutation. However, there is significant variability observed in disease expression likely due to the influence of other environmental, lifestyle, or ...
Amos, Christopher I, Broaddus, Russell, Chen, Jinyun, Frazier, Marsha L, Lynch, Patrick M, Osterwisch, Daniel R, Pande, Mala   +6 more
core   +1 more source

Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population

Neuropsychiatric Disease and Treatment, 2021
Birsen Can Demirdöğen,1 Yağmur Miçooğulları,2 Aysun Türkanoğlu Özçelik,3 Orhan Adalı4 1Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey; 2Institute of Natural and Applied ...
Can Demirdöğen B, Miçooğulları Y, Türkanoğlu Özçelik A, Adalı O   +3 more
doaj