Results 81 to 90 of about 6,917 (192)
Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 5, Page 620-640, November 2024.Abstract Asphyxiated neonates often undergo therapeutic hypothermia (TH) to reduce morbidity and mortality. As perinatal asphyxia and TH impact neonatal physiology, this could also influence enzyme functionality. Therefore, this study aimed to unravel the impact of age, hypothermia and hypoxia on porcine hepatic cytochrome P450 (CYP) gene expression ...
Marina‐Stefania Stroe +11 more
wiley +1 more source
Association of functional variants of phase I and II genes with chronic obstructive pulmonary disease in a Serbian population [PDF]
Journal of Medical Biochemistry, 2015 Background: Chronic obstructive pulmonary disease (COPD) is a complex disorder characterized by increased oxidative stress. Functional genetic variants of phase I and II genes are implicated in oxidants-antioxidants imbalance and may be involved in COPD ...
Stanković Marija +6 more
doaj
Clinical Pharmacology &Therapeutics, Volume 116, Issue 4, Page 963-975, October 2024.The Pharmacogene Variation Consortium (PharmVar) serves as a global repository providing star (*) allele nomenclature for the polymorphic human CYP4F2 gene. CYP4F2 genetic variation impacts the metabolism of vitamin K, which is associated with warfarin dose requirements, and the metabolism of drugs, such as imatinib or fingolimod, and certain ...
Pablo Zubiaur +13 more
wiley +1 more source
Properties of epoxide hydrolase from the yeast Rhodotorula glutinis [PDF]
Epoxide hydrolases are ubiquitous enzymes that can be found in nearly all living organisms. Some of the enzymes play an important role in detoxifying xenobiotic and metabolic compounds.
Ariës-Kronenburg, N.A.E.
core +1 more source
Vestibulotoxic properties of potential metabolites of allylnitrile [PDF]
, 2015 This study addressed the hypothesis that epoxidation of the double bond in allylnitrile mediates its vestibular toxicity, directly or after subsequent metabolism by epoxide hydrolases.
Bayona i Termens, Josep Maria +9 more
core +2 more sources
British Journal of Clinical Pharmacology, Volume 90, Issue 9, Page 2137-2158, September 2024.Aim Understanding how COVID‐19 impacts the expression of clinically relevant drug metabolizing enzymes and membrane transporters (DMETs) is vital for addressing potential safety and efficacy concerns related to systemic and peripheral drug concentrations.
Chukwunonso K. Nwabufo +6 more
wiley +1 more source
Genotoxicity characteristics of reverse diol-epoxides of chrysene [PDF]
, 2017 Trans-3,4-dihydroxy-3,4-dihydrochrysene (chrysene-3,4-diol), a major metabolite of chrysene, is further metabolized by rat liver enzymes to products which effectively revert the his− Salmonella typhimurium strain TA98 to histidine prototrophy, but are ...
Elsberg, Sabine +8 more
core
A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes:Regulation by the Constitutive Androstane Receptor [PDF]
, 2013 The modulation of drug metabolism enzyme (DME) expression by therapeutic agents is a central mechanism of drug-drug interaction and should be assessed as early as possible in preclinical drug development.
Henderson, Colin J. +5 more
core +5 more sources
The Journal of Clinical Pharmacology, Volume 64, Issue 8, Page 993-1005, August 2024.Abstract BI 187004, a selective small‐molecule inhibitor of 11β‐hydroxysteroid dehydrogenase‐1 (11β‐HSD1), displayed complex nonlinear pharmacokinetics (PK) in humans. Following nine single oral doses, BI 187004 exhibited nonlinear PK at low doses and linear PK at higher doses.
Xuanzhen Yuan, Guohua An
wiley +1 more source