Results 261 to 270 of about 96,126 (327)

Endocyclic Trisubstituted Hydroxylamine Isosteres of Basic Amines for ADME Modulation and Reduction of hERG Activity. [PDF]

ACS Med Chem Lett
Khan I, Hettikankanamalage AA, Cui Y, Crich D.   +3 more
europepmc   +1 more source

Potent Neuronal Nicotinamide Adenine Dinucleotide-Boosting Tetrahydroquinoxalines: Structure-Activity Relationships and Early Drug Metabolism and Pharmacokinetics Evaluation. [PDF]

ACS Med Chem Lett
Cuřínová P, Jöe M, Cesar F, Nicol A, Schwan K, Kohout M, Varrichio C, Saleh A, Wheelock CE, Jóhannesson G, Eigner V, Tribble JR, Brancale A, Williams PA.   +13 more
europepmc   +1 more source

Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines. [PDF]

Arch Toxicol
Ravi Shankar AL, Irwan J, Spaenig M, Carlier M, Hansen T, Zumbülte N, Islam B, Lundquist P, Svensson R, Gouin T, Hamers T, Escher SE.   +11 more
europepmc   +1 more source

Cytochrome P450 drug metabolism and protein induction and inhibition in fish liver microsomes

, 2009
Emily M. Smith
openalex   +1 more source

Comprehensive <i>in vivo</i> and <i>in vitro</i> metabolic profiling of amphenmulin: a novel pleuromutilin derivative characterized by UHPLC-Q-TOF-MS/MS. [PDF]

Front Vet Sci
Wang W, Wang L, Deng Q, Su D, Tang Y, Ding H.   +5 more
europepmc   +1 more source

The Human Monoacylglycerol Acyltransferase 2 Inhibitor VB-85387 Is Associated With Weight Loss in Mice With Obesity. [PDF]

Obes Sci Pract
Corbalan JJ, Jagadeesan P, Huang CY, Beasley JR, Nickels JT.   +4 more
europepmc   +1 more source

Design, Synthesis, and Structure-Activity Relationships of Substituted Phenyl Cyclobutylureas as Potential Modulators of Inflammatory Responses. [PDF]

Pharmaceuticals (Basel)
Chavez Alvarez AC, Carpentier A, Sahli A, Perreault M, Ngon AD, Moreau E.   +5 more
europepmc   +1 more source

Protocol for screening inhibitors of the fungal sphingolipid-metabolizing enzyme ceramide synthase. [PDF]

STAR Protoc
Zhong A, Dasilva D, Pereira de Sa N, You JK, Del Poeta M.   +4 more
europepmc   +1 more source

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Microsomal Proteomics

2009
Proteomic profiling of subcellular compartments has many advantages over traditional proteomic approaches using whole cell lysates as it allows for detailed proteome analysis of a specific organelle and corresponding functional characteristics. The microsome is a critical, membranous compartment involved in the synthesis, sorting, and secretion of ...
Diana M, Wong, Khosrow, Adeli
openaire   +2 more sources