Results 191 to 200 of about 63,716 (263)

Retinal Microvasculature and Emotional, Behavioral, and Cognitive Outcomes at School Age. [PDF]

J Am Heart Assoc
Gonçalves R, Defina S, Cecil CAM, Steegers EAP, Gaillard R, Jaddoe VWV.   +5 more
europepmc   +1 more source

High‐elevation adaptation and gestational hypoxia jointly shape vascular development in a rodent placenta

The Journal of Physiology, EarlyView.
Abstract figure legend We investigated how environmental hypoxia and genetic adaptation to high altitudes jointly impact the development of the placental exchange surface in ways that might protect fetal growth potential. We used wild‐derived, lab‐born North American deer mice (Peromyscus maniculatus) from low‐elevation and high‐elevation environments (
Kathryn Wilsterman, Zachary A. Cheviron, Jeffrey M. Good, Kai Gurnoe‐Brantley, Kylie E. Jewett, Katherine Kiel, Ashley M. Larson   +6 more
wiley   +1 more source

Structural Characteristics of Parapapillary Choroidal Microvasculature Dropout in Primary Open-Angle Glaucoma: Comparison Between Width and Area. [PDF]

Clin Ophthalmol
Lee SH, Seo JH, Moon GY, Huang AS, Kim TW, Lee EJ.   +5 more
europepmc   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

No-reflow in acute ischemic stroke: mechanisms, measurements, and molecular markers. [PDF]

Front Neurol
Bayona H, Granja MF, Useche JN.
europepmc   +1 more source

Human placental transfer of xenobiotics in health and disease: New approach methodologies for developmental and reproductive toxicology testing and mathematical modelling

The Journal of Physiology, EarlyView.
Abstract figure legend New approach methodologies (NAMs) to test the pharmaco‐ and chemicokinetics of compound transfer across the human placental barrier in late pregnancy. Abstract This review addresses an important and timely topic at the intersection of placental biology with respect to barrier transfer kinetics, toxicology and mathematical ...
Paul Brownbill, Eleanor Doman
wiley   +1 more source

Retinal Microvascular Alterations in Diabetic Patients Assessed with Novel Imaging Techniques. [PDF]

Life (Basel)
Liśkiewicz-Jankowska M, Dąbrowska E, Wolf J, Narkiewicz K.   +3 more
europepmc   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

Distinct ocular microvascular alterations in Alzheimer's disease and cerebral small vessel disease. [PDF]

Alzheimers Dement
Zhang Z, Cao L, Liu P, Yang S, Yan Y, Kwapong WR, He Y, Yang M, Wang H, Wang Y, Feng Z, Zhou J, Liu M, Lei P, Wu B, Zhang S.   +15 more
europepmc   +1 more source

Skeletal muscle adaptation to muscle activity and hypoxia: Differential structural and metabolic remodelling

The Journal of Physiology, EarlyView.
Abstract figure legend There has been controversy about the structural (capillary) response of skeletal muscle to altered O2 status, involving decreased supply (hypoxia) or increased demand (activity). Here we demonstrate that seven days of activation of skeletal muscle by indirect electrical stimulation led to significant expansion of the capillary ...
David Hauton, Roger W.P. Kissane, James McCullagh, Stuart Egginton   +3 more
wiley   +1 more source