Results 261 to 270 of about 51,231 (331)

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

open access: yesAdvanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu   +34 more
wiley   +1 more source

Food‐Activated Microneedle Sensor for Real‐Time, Colorimetric Spoilage Monitoring of Pre‐Packaged Food

open access: yesAdvanced Science, EarlyView.
A microneedle spoilage sensor for packaged food products is presented. The sensor is composed entirely of food‐derived agents, integrated together using a novel material processing approach. This resultant platform nondestructively reports spoilage state in real‐time through a colorimetric output.
Shadman Khan   +5 more
wiley   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

open access: yesAdvanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan   +19 more
wiley   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

open access: yesAdvanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng   +7 more
wiley   +1 more source

Supramolecular Phase Change Materials for Spatiotemporally Thermal Energy Utilization

open access: yesAdvanced Science, EarlyView.
The long‐term storage as well as switchable and controllable release of thermal energy using activated perethylated pillar[5]arene EtP5 (EtP5α) is demonstrated for the first time. High thermal energy storage capacity can be maintained over 20 thermal cycles and for more than 365 days at room temperature, which is the PCMs that can store thermal energy ...
Miaomiao Yan   +5 more
wiley   +1 more source

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