Results 91 to 100 of about 28,063 (287)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Monitoring Alkalinity and Hardness During Treatment of Different Water Types

Al-Khawarizmi Engineering Journal
Alkalinity and hardness are crucial factors in water treatment procedures, such as electrocoagulation (EC) and traditional coagulation–flocculation. Two types of water were employed in this study to investigate the use of EC: river water and discarded ...
Shahad F. AlRubaye, Naseer A. Al Haboubi , Hussein A. Al-Amili , Aiman H. Al-Allaq, Dina R. Rzaij   +4 more
doaj   +1 more source

Egyptian funerary boat model in the Australian Museum: dating and analysis

Records of the Australian Museum, 2021
The unprovenanced and stylistically unusual wooden boat model (AM E60381) from the Australian Museum collection is examined to assess its identity and age.
Stan Florek, Heather Bleechmore, Jana Jones, Colin McGregor, Ross Pogson, Jim Specht   +5 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Using Ubicomp systems for exchanging health information : considering trust and privacy issues [PDF]

, 2006
Ambient Intelligence (AmI) and ubiquitous computing allow us to consider a future where computation is embedded into our daily social lives. This vision raises its own important questions and augments the need to understand how people will trust such ...
Briggs, Pamela, Little, Linda
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Experience of middle-class study in the world and in Russia

Современная зарубежная психология, 2012
The article is concerned with the problem of how to single out and study the middle class as a social group. The reviewed publications set up the ground for discussion, concerning the history of «middle class» studies in sociology and social psychology ...
A.S. Moiseev
doaj  

Age-related changes of pubic symphysis parameters in men in the early adulthood, early and middle old age according to computed tomography data [PDF]

Наука и инновации в медицине
Aim – to study the dynamics of pubic symphysis parameters in men in the early adulthood, early and middle old age according to computed tomography (CT) data. Material and methods. In the study, we used the results of a CT examination of 80 men without
Irina A. Balandina, Aleksandr S. Terekhin, Anatolii A. Balandin, Aleksei V. Klimets   +3 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Risk of Traumatic Intracranial Hemorrhage From Low-Energy Falls in the Oldest-Old Patients

Annals of Geriatric Medicine and Research, 2016
Background: The population of individuals classified as oldest-old (aged ≥85 years) has increased rapidly in recent years. The rates of morbidity from chronic diseases and physical dependence tend to be higher in the oldest-old compared with individuals ...
Sung Kyu Kim, Ki Young Jeong, Jong Seok Lee, Han Sung Choi, Hoon Pyo Hong, Young Gwan Ko   +5 more
doaj   +1 more source