Results 111 to 120 of about 1,054,489 (297)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Old and New Testament figures in Mandaean version
Scripta Instituti Donneriani Aboensis, 1969 The religion which is commonly called the Mandaean is certainly a most complex entity. There is no standardized doctrine. Neither anthropology, cosmogony nor soteriology have reached that stage of doctrinal clarity which in the West is regarded as ...
Eric Segelberg
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Fall Risk Among Urban Community Older Persons [PDF]
, 2013 The elderly should be screened in the community for risk for falls. It impacts significantly on their ability to still be active and productive even during aging. This study determined the risk for falls among Philippine urban community-dwellers 65 years
Valera, M. J. (Mary)
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The effect of childhood socioeconomic status on depressive symptoms in middle-old age: the mediating role of life satisfaction. [PDF]
BMC Psychiatry, 2022 Tang L, Yin R, Hu Q, Fan Z, Zhang F.
europepmc +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Infinitive fronting as a transparency effect in Old and Middle French
IsoglossIn this article, we present a novel analysis of infinitive fronting in Old and Middle French (9th-16th century). We find that in sentences with modal verbs and clitic climbing, the infinitive may either follow the main verb or precede it.
Marc Olivier +2 more
doaj +1 more source
Association between Oral Frailty and Physical Frailty among Rural Middle-Old Community-Dwelling People with Cognitive Decline in Taiwan: A Cross-Sectional Study. [PDF]
Int J Environ Res Public Health, 2022 Kuo YW, Lee JD.
europepmc +1 more source