NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Retirement expectations and effects : a thesis presented in fulfilment of the requirements for the degree of Master of Arts in Social Anthropology at Massey University [PDF]
, 1987 In New Zealand, as in other Western societies, retirement has become a distinct and lengthy phase of the life-cycle. Some researchers have directed attention towards this topic but at present the potential for in-depth research on people in later life is
Scotney, Tere
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Employment protection legislation and job stability: an European cross country analysis [PDF]
This paper tries to shed some light on the actual changes that occurred in the labour markets dynamics of the European Union 253 (EU-25) over the last decade using job tenure4 data.
Cazes, Sandrine, Tonin, Mirco
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Psychometric Properties of the EQ-5D for the Assessment of Health-Related Quality of Life in the Population of Middle-Old and Oldest-Old Persons: Study Protocol for a Systematic Review. [PDF]
Front Public Health, 2020 Gottschalk S +3 more
europepmc +1 more source
Financial Structure, Informality and Development [PDF]
This is a theory of total factor productivity based on measured capital market im- perfections and costs of creating and operating formal sector firms.
Hernan J Moscoso Boedo +1 more
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A Study on Emotional Burnout among Middle-Old Aged Double Caregivers
Family and Culture, 2018 null 송다영 +2 more
openaire +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source