Results 131 to 140 of about 2,065,806 (262)

Blood Pressure in Adolescence and Atherosclerosis in Middle Age.

JAMA Cardiol
Herraiz-Adillo Á, Eriksson H, Ahlqvist VH, Ballin M, Wennberg P, Daka B, Lenander C, Berglind D, Östgren CJ, Lundgren O, Rådholm K, Henriksson P.   +11 more
europepmc   +1 more source

Lipid accumulation product and its association between new onset stroke among middle age and elderly population. [PDF]

BMC Cardiovasc Disord
Xu Y, Li Z, Wu SY, Zhu XM.
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Middle-age healthcare spending and utilization at the intersection of comorbidities, functional limitation, and race/ethnicity. [PDF]

Innov Aging
Toseef MU, Sultana S, Samuel P, Tarraf W.   +3 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle-Age and Older Men With Low Testosterone. [PDF]

Aging Cell
Nguyen BL, Kehmeier MN, Babcock MC, DuBose LE, Hildreth KL, Stauffer BL, Rosenberry R, Keller AC, Steinke K, Miles K, Guerrero L, Kohrt WM, Reusch J, Clayton ZS, Moreau KL.   +14 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Neural Coding of Fundamental Frequency and Processing of Discrete Pitch Accents in Middle Age. [PDF]

Eur J Neurosci
McHaney JR, Guo ZC, Gnanateja GN, Parthasarathy A, Chandrasekaran B.   +4 more
europepmc   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Association of cumulative deficit frailty with brain age and Alzheimer's disease-related brain structure starting in late-middle age. [PDF]

J Gerontol A Biol Sci Med Sci
Hunt JFV, Buchholz EJ, Franz CE, Reynolds CA, Panizzon MS, Williams ME, Bell TR, Tang R, Hagler DJ, Gillespie N, Elman JA, Neale MC, Dorros S, Dale AM, Kremen WS, Fennema-Notestine C, Vietnam Era Twin Study of Aging.   +16 more
europepmc   +1 more source