Results 151 to 160 of about 2,065,806 (262)

Development of a physical performance summary score in middle age: Findings from the CARDIA Function study. [PDF]

Am J Epidemiol
Burrows BT, Sloane R, Faldowski R, Pieper C, Lewis CE, Gabriel KP, Jacobs DR, Bowling CB.   +7 more
europepmc   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

MIDDLE AGE [PDF]

, 2015
openaire   +1 more source

Chronic pain and mortality risk among middle-age and older Japanese: the Shika town cohort study. [PDF]

Pain Rep
Camara J, Tsujiguchi H, Hara A, Inagaki Y, Nakamura M, Takazawa C, Suzuki K, Miyagi S, Suzuki F, Kasahara T, Asai A, Katano K, Sato K, Ogawa A, Fukushima S, Tsuboi H, Shimizu Y, Shibata A, Kambayashi Y, Kannon T, Zhao J, Marama T, Takeshita Y, Tajima A, Takamura T, Nakamura H.   +25 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cerebral blood flow is associated with plasma and PET biomarkers of tau pathology in middle age. [PDF]

Brain Commun
Houck AL, Alshikho MJ, Lao PJ, Pyne JD, Turney IC, Mazen J, Benavides A, Hale C, Herman M, Berroa J, Edwards NC, Gutierrez J, Simoes S, Manly JJ, Brickman AM.   +14 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Combined effects of insulin resistance and dyslipidaemia on cardiometabolic multimorbidity in Chinese middle-age and older adults: a longitudinal cohort study. [PDF]

Sci Rep
Wang H, Zhang H, Zhang L, Zheng X, Yang M.   +4 more
europepmc   +1 more source