Efficacy and Mechanism EvaluationBackground Long-term surviving liver transplant recipients can spontaneously develop operational tolerance, which allows them to completely discontinue their immunosuppression, but we lack validated tools to predict the likelihood of rejection following ...
Julien Vionnet +22 more
doaj +1 more source
The Life Functioning Scale: A Measurement Tool Developed to Assess the Physical Functioning Abilities of Community-Dwelling Adults Aged 50 Years or Older [PDF]
Annals of Geriatric Medicine and ResearchBackground This study aimed to develop an instrument for assessing physical functioning among adults aged 50 years or older living in the community. Methods Based on a review of various national health surveys and cohort studies, a 144-item bank was ...
Yunhwan Lee +9 more
doaj +1 more source
Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients
Journal of Infection, 2020 Kai Liu, Ying Chen, R. Lin, Kunyuan Han
semanticscholar +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Association Between Shift Work and Auditory–Cognitive Processing in Middle-Aged Healthcare Workers
Audiology ResearchBackground/Objectives: Shift work in healthcare professionals affects performance in high cognitive processing, especially in complex environments.
Margarida Roque +2 more
doaj +1 more source
Anticholinergic drug use and cognitive performances in middle age: findings from the CONSTANCES cohort [PDF]
, 2018 Abdelkrim Ziad +7 more
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Prevalence of High-Burden Medical Conditions Among Young and Middle-Aged Adults With Pediatric-Onset Medical Conditions: Findings From US Private and Public Administrative Claims Data [PDF]
, 2019 Daniel G. Whitney
openalex +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source