Results 171 to 180 of about 11,148,453 (358)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Two Masters of Surgery in Parma during the Middle Ages. [PDF]
Acta Biomed, 2020 Cervellin G +3 more
europepmc +1 more source
4. Roger Bacon and Medieval Science
, 1958 Throughout the Middle Ages there was little interest in theoretical science as such. Not since the Greeks had nature been considered a sufficient object in and of itself for most of the study that we would call scientific.
Bloom, Robert L. +6 more
core
Impact of modifiable healthy lifestyle adoption on lifetime gain from middle to older age [PDF]
, 2022 Ryoto Sakaniwa +5 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Historicising stress: anguish and insomnia in the middle ages. [PDF]
Interface Focus, 2020 MacLehose W.
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Different Approach to Horses-The Use of Equid Remains in the Early Middle Ages on the Example of Ostrów Tumski in Wroclaw. [PDF]
Animals (Basel), 2020 Jaworski K +3 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source