Results 91 to 100 of about 471,464 (304)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Thermal characteristics study of light aggregate concrete of the middle Atlas pozzolana

MATEC Web of Conferences, 2018
We present in this work an experimental study of the thermomechanical characterization of pozzolan (volcanic rock widespread in the region of Azrou in the Middle Atlas in Morocco).
Bouyahyaoui A., Cherkaoui M., Abidi My L., Cherradi T.   +3 more
doaj   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Structure and evolution of the Neogene Guercif Basin at the junction of the Middle Atlas Mountains and the Rif thrust belt

, 2000
Copyright 2000, AAPG. See also: http://www.aapg.org/bulletin/index.cfm; http://atlas.geo.cornell.edu/morocco/publications/gomez2000AAPG.htmThe Guercif basin of northern Morocco occupies a 50 x 60 km area where the transpressional Middle Atlas ...
Barazangi, M., Demnati, A., Gomez, F.
core  

The LHC mass limits for the $SU(2)_{L+R}$ vector resonance triplet of a strong extension of the Standard model

, 2017
In this paper, we derive the mass exclusion limits for the hypothetical vector resonances of a strongly interacting extension of the Standard model using the most recent upper bounds on the cross sections for various resonance production processes.
Gintner, Mikulas, Juran, Josef
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Evidence of remagnetized red-beds in the Middle Atlas (Morocco) [PDF]

, 2017
Se ha realizado un estudio paleomagnético en el límite entre el Atlas Medio Plegado y el Atlas Medio Tabular, en el entorno de los sinclinales de Skoura y Tighboula y el anticlinal de Boulemane.
Calvín Ballester, Pablo, Mahmoudi, Abdelkader ., Villalaín Santamaria, Juan José   +2 more
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Exploring climatic variability and drought characteristics in Morocco’s Sais Plateau and Middle Atlas: A statistical and spectral analysis [PDF]

BIO Web of Conferences
Extreme climate change phenomena are a global reality with major repercussions on hydrosystems. Drought is particularly concerning in the southern Mediterranean region, threatening water availability and related behavior. Morocco, located in North Africa
Qadem Zohair, Ettaqy Abderrahim
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source