Results 81 to 90 of about 122,580 (304)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

CU.047 Middle Atlas Mountains

, 1974
Lush green landscape of the Middle Atlas mountains.
Baly, Denis
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

CU.045 Middle Atlas Mountains

, 1974
Lush green landscape of the Middle Atlas mountains.
Baly, Denis
core  

A Parsed Linguistic Atlas of Early Middle English

, 2018
A parsed version of part of the Linguistic Atlas of Early Middle English (LAEME), annotated in the format of the Penn Parsed Corpora of Historical English.
Donaldson, James, Leverhulme Trust, School of Philosophy, Psychology and Language Sciences, British Academy, Truswell, Robert, Alcorn, Rhona   +5 more
core   +1 more source

Thermal characteristics study of light aggregate concrete of the middle Atlas pozzolana

MATEC Web of Conferences, 2018
We present in this work an experimental study of the thermomechanical characterization of pozzolan (volcanic rock widespread in the region of Azrou in the Middle Atlas in Morocco).
Bouyahyaoui A., Cherkaoui M., Abidi My L., Cherradi T.   +3 more
doaj   +2 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

CU.048 Middle Atlas Mountains

, 1974
Lush green landscape of the Middle Atlas mountains.
Baly, Denis
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

CU.037 Middle Atlas Mountains

, 1974
Cattle on Berber settlement near the Middle Atlas Mountains.
Baly, Denis
core