Results 61 to 70 of about 122,580 (304)
CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu +8 morewiley +1 more sourceTranscriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel +14 morewiley +1 more sourceJet energy resolution in proton-proton collisions at root s=7 TeV recorded in 2010 with the ATLAS detector [PDF]
, 2012 Atlas Collaboration contributor: Paul Douglas Jackson of SLAC National Accelerator Laboratory, Stanford CA, United States of America. Extent: 27p.The measurement of the jet energy resolution is presented using data recorded with the ATLAS detector in ...G. Khoriauli, Alessandria, F, S. O. Holmgren, Arce ATH, Smizanska, M, Blair, R, Keung, J, Ask S., Strang, M, Hasegawa, S., G. Eigen, Aguilar-Saavedra, J. A., Carminati, L., C. Le Maner, Cantero, J., Hubaut, F., M. Mazur, E. Etzion, P. Hansson, Meyer, C., Dudarev, A., Skottowe, H, Oren, Y., Borissov, G., F. Dinut, Hellman, S, Harper, D, Korn, A., Oliver García, Elena, Laplace, S., Kluges, E, Y. Smirnov, Higón Rodríguez, Emilio, D. Chakraborty, Kim, H., Bona M., Cavalli Sforza, M, Kanzaki, J, C. Booth, Schaefer, D., J. M. Seixas, A. Talyshev, Norton, PR, T. Naumann, Pranko, A, Epp, B., Hawkings, R. J., Clark A., Jakoubek, T, Fernando, W, Ahlen, S. P., Froeschl, R., J. Keung, G. Nunes Hanninger, Brooijmans G., Leney, K, Joshi, K. D., J. Tojo, Dameri, M., Daya-Ishmukhametova, R, Butler J. M., M. Villa, Huettmann, A, Pizio, C., Eldik, N., A. Tonoyan, W. J. Dearnaley, B. Caron, Jon-And, K., Bundock A. C., Acharya B. S., Köneke, K., Tasevsky, M., Siragusa, G, Gregor, I. M., Salzburger, A., Rossi, LP, S. Kaneti, Hadley, DR, Vacek, V, Carlino, G., Torrence, E., Oliveira, M, Bogaerts, J, I. Gough Eschrich, Snyder, S, Kirk, J, Ziolkowski, M, P. Grenier, Korotkov, VA, Kourkoumelis, C., V. Dao, Oh, S. H., Dai, T., Lefebvre, M, T. Mueller, M. Uslenghi, Bernat, P., G. Alexandre, I. N. Aleksandrov, Engl, A, A. Juste Rozas, Asai S, Arnault, C., Bortolotto, V, Kiryunin, A, Anh, TV, Genest, MH, M. Klein, Negri, G., Moreno Llácer, María, Valkar, S, D. M. Rebuzzi, T. Todorov, Caminada L. M., T. Sumida, Olszewski, A., Knue, A, M. Medinnis, L. Mijović, Harris, O, D. Turecek, Hughes, G., Cheatham, S, Joram, C, Mashimo, T, Flores Castillo, L, M. H. Genest, P. Stavina, Smizanska, M., Montoya, G. D. Carrillo, Hughes, EW, Nelson, T. K., Padilla Aranda, C., Kersten, S, Pérez García-Estañ, M. T., Weng, Z., Schaepe, S., Schovancova, J., M. S. Weber, Reale, V, Sircar, A., Vassilakopoulos, V, Oliveira, Miguel Alfonso, Bruneliere, R, S. Menke, Darlea, G, M. Agustoni, Massol, N, Potter, C. T., Benoit M, Morello, G., L. Rumyantsev, Canelli F., Negri, A., Kawamoto, T, K. Tackmann, Castaneda Miranda, E, Schamberger, RD, J. E. García Navarro, Ji, W., Teng, P. K., Michal, S, R. Camacho Toro, Lombardo, VP, D. G. Charlton, Salihagic, D, Karnevskiy, M., B. Budick, J. Zhu, Wiik-Fuchs, LAM, Liu, C., Bronner, J., J. B. Liu, J. Toth, González de la Hoz, Santiago, Ertel, E., Cornelissen, T, Schwierz, R., J. L. Pinfold, Vincter, M. G., Kim, SH, D’Orazio, A., Fedin, OL, Barr, A, J. Griffiths, Köpke, L., Nisati, A, Strong, J, M. F. Tripiana, Deviveiros, P, M. Werner, Marx, M, V. B?scher, A. F. Saavedra, Liu, D., A. Ludwig, Burckhart H., V. Vrba, Selbach, K, V. Andrei, M. Wright, A. Petridis, Orr, R, O. Le Dortz, Lellouch, D., G. Cataldi, Bini, C, Hedberg, V, A. Boveiam, D. A. Milstead, Ferretti, C., Kobel, M, E. Pasqualucci, Bednyakov, V, Lubatti, H, A. Polini, Puzo, P, Salvachua Ferrando, B. M., Nozka, L, Yu, J, R. Veness, Da Cunha Sargedas De Sousa, Mario Jose, Lancon, E, Marroquim, F, Yu, D, Z. Zhang, Yu, E, Abdelalim, A. A., Liss, T, Johansson, K. E., Ellis, N, Benslama, K., Ellis, K, Norberg, S, Poel, E., Kolanoski, H., Baak, M, zur Nedden, M., Allwood Spiers, S. E., Bates, RL, Kowalewski, R., Sjölin, J., K. Iordanidou, Oreglia, M, Wells, P. S., Parzefall, U, Hillier, S, T. Nattermann, Samset, BH, Woudstra, MJ, Huseynov, N, Bellina, F, N. Benekos, Medinnis, M., Charlton, D. G., R. Bates, Sadrozinski, H, Andreazza, Attilio, Arnault C., Tamsett, MC, Zhou, Y., Pauly, T, V. Kral, Lopes, Lourenco, Errede, S., Liu, H., F. Niedercorn, R. Ueno, Petrucci, F., Rijssenbeek, M., Kaci, M, R. Ströhmer, Marchese, F., Krumshteyn, Z, T. Kuhl, G. Romeo, Dwuznik, M., Shatalov, PB, Smirnova, O, Arguin, J-F., Doi, Y., B. Vachon, Cooke, M., Smirnova, L, Richter, R., S. Schmitt, Diehl, E, Oberlack, H, Olchevski, A. G., L. Serkin, Avolio, G, Beau T., Broggi F., M. Garcia-Sciveres, Dolgoshein, B. A., Castillo Gimenez, V., Juste Rozas, A, T. M. Liss, Nikolic-Audit, I, Weng, Z, Sw. Banerjee, M. C. N. Fiolhais, Milov, A, A. J. Lowe, R. Seuster, Haller, J, P. Loch, E. Piccaro, Buat, Q., Donadelli, M., S. Monzani, Taylor, F. E., Blair, RE, Donadelli, M, McFarlane, K. W., Ros, E., Ciocca, C., G. Bobbink, Lipeles, E., R. Bartoldus, Tripiana, M. F., Bhimji W, Epp, B, Rybar, M, H. M. Gray, Cantrill, R, Zobernig, G., Kroha, H, Coccaro, A., Gössling, C., Clark PJ, Tsiareshka, PV, Meroni, C, Tayalati, Y, Ciftci AK, Branchini P, Y. Bai, Lie, K, Davygora, Y., Kawamura, G, Solovyev, V., Cardarelli R., E. Sarkisyan-Grinbaum, S. Bentvelsen, Davies, M, Byszewski, M, Pommès, K., Andeen T, Strang, M., Klemetti, M, Conde Muiño, P., Davies, E, Blumenschein U, Keung, J., Ippolito, V., Camacho Toro, Reina Coromoto, Lantzsch, K., Sbrizzi, A., Gray, J. A., Buchholz P., Fournier, D., Y. Makida, Straessner, A., Fiorini, L., Tylmad, M., C. Bertella, M. G. Wilson, Dudarev, A, Busato E, Schroeder, C., L. Batkova, W. Bell, A. Dudarev, E. Ertel, Lange, C, Chafaq, A., Lantzsch, K, Grivaz, J.-F., Battistin M, Francavilla, P., Gorini, B., Wiglesworth, C., Bromberg C., P. Wienemann, Hansen, J. B., Ueda, I., Beddall, A, Kroha, H., Tsiskaridze, V, Alhroob, M., Tsiskaridze, S, S. Heisterkamp, Kurata, M, Ren, Z, Salek, D, P. Calfayan, Maettig, S, G. Anders, Zevi della Porta, G., Lane, JL, Aliev M., J. M. Izen, Fisher, M, Lobodzinska, E., CHIEFARI, GIOVANNI, H. G. Sander, Bartoldus, R., Bagnaia P, Lagouri, T, Maettig, P, J. Ebke, Patricelli, S., Verducci, M., Goussiou, AG, P. A. Bruckman, Odaka, S, Wielers, M., Nikolic-Audit, I., Kononov, AI, Abi, babak, D. C. O’Neil, Walsh, B, D. S. Popovic, Hansen, J. D., Barajas, C, S. Cole, de Jong, P., H. Ji, Vermeulen, J. C., E. Vilucchi, Da Cunha Sargedas De Sousa, MJ, Schorlemmer, A. L. S., J. Lorenz, L. Manhaes de Andrade Filho, P. Vankov, A. Gibson, Baranov, S, J. R. Carter, Chislett, RT, Mechnich, J., Hadavand, H. K., Baranov S. P., Soukharev, A, S. Vallecorsa, Ciftci, R., M. T. Pérez García-Estañ, M. Raymond, AbouZeid, Ossama Sherif, Oliver Garcia, E., X. S. Anduaga, C. Stanescu, Strube, J., Hajduk, Z, S. Mahmoud, Zhou, B., Schwemling, Ph., Alexandre, G, Aleksandrov IN, Tovey, DR, Burgess, T., Kado, M., Khubua, J., Spagnolo, S., M. Pohl, Ikeno, M., M. Ciubancan, C. De La Taille, Brendlinger, K, Bocchetta, S, Gagnon, P., F. Hahn, Klok, P, Nakahama, Y., J. Kroseberg, J. Labbe, H. Li, Chen Y., P. J. Clark, Rybar, M., Schumm, BA, Popeneciu, G. A., Aharrouche, M, G. Alexander, H. Ma, Bremer, J., Cowan, G, Gadfort, T, AbouZeid, O, Ekelof, T., Chromek Burckhart, D., Shupe, M, Chen X., Kluth, S., Cakir O., P. Cirkovic, Errede, D., Sipica, V., El Moursli, RC, Steele, G., Levinson, L. J., Calafiura P., Beloborodova O, Seidel, SC, Cattai, A., Biesiada J., O’Neil, D. C., Piec, S. M., Hryn'ova, T, Sartisohn, G., D’Auria, S., Brandt G., M. Schumacher, P. Federic, Ladygin, E., Rubinskiy, I., Fratina, S., J. Meyer, Makovec, N, Lundberg, B, L. A. Bella, Kabana, S., J. Buchanan, Lundberg, J, Bruschi, M, S. Allwood Spiers, A. M. Castaneda, Lundberg, O, Giorgi, F, Sauvage, G, Bednyakov, V. A., Gorini, E., Zhou, N., Poveda, J., Grosse-Knetter, J., Frank, T, Azuelos, G, Cerutti, F, Cheplakov A., Petrolo, E., G. L. Darlea, Murray, W. J., R. Hauser, Bouhova-Thacker EV, Vladoiu, D, Hansen, J. R., Calvet, D., Blocker C., L. Fayard, Alami, M, H. Schulz, Nanava, G, Slater, M., Curatolo, M., Djobava, T., G. Poulard, N. Amram, V. B. Vinogradov, Hassani, S, M. Morii, Cavalleri P., Teixeira Dias Castanheira, M., Hillert, S, Cavasinni V., Wingerter-Seez, I., Krieger, N, P. Gerlach, Rossi, E., Krieger, P, Boumediene D., D. Kar, B. Liberti, Childers, J, B. H. Smart, García García, Carmen, G. Lenzen, Taylor, FE, Bawa, HS, Keeler, R., F. Derue, M-A. Dufour, Brandt A., Maltezos, S., Chu, M. L., T. Djobava, Belotskiy K., Stelzer-Chilton, O., P. W. Phillips, Wong, WC, H. G. Wilkens, Potter, C. J., Simic, L, Bachacou H., Brelier B, Anduaga XS, Saleem, M., C. Schiavi, Dhullipudi, R., Stradling, AR, Kar, D., Subramania, H, T. Nunnemann, A. Salamon, B. M. M., Laporte, JF, S. Stern, Taylor, C., K. Bos, Kishimoto, T., Goddard, J. R., Mechtel, M, Bardin, DY, Ancu L. S., Lehmacher, M., Nugent, IM, Kono, T, Cerrito L., Bunse M., M. Caprini, Juste Rozas, A., J. Rothberg, Buttinger, W., T. Wenaus, St Denis, RD, Bitenc U, Paramonov, A, Joffe, D, Farrell, S, Seliverstov, D. M., Gray, H, Ženiš, T., Ramos, JAM, Gray, J, F. Quinonez, Rosenbaum, G, Blocker C, Gillberg, D, B. K. Gjelsten, D. M. Gingrich, Banas, E., Losty, M. J., Tani, K., Zhu, J., Bianchi, R. M., Esposito, B, J. Schaarschmidt, Beau T, Milov, A., Roda Dos Santos, D., Bacci, C, T. Nobe, T. Colombo, B. Guo, D. Rahm, Grishkevich, Y. V., Malecki, Pa., Tani, K, V. Martinez Outschoorn, Harris, OM, Zhu, H., Ciocca, C, Wu, SL, Einsweiler, K., Haller, J., Kortner, O., Venturi, M., Bell W. H., T. Kobayashi, Brandt O., Catastini, P, O. Simard, Mechnich, J, Prokoshin, F, C. P. Paleari, De Groot, N, Weigell, P, Andrei, Victor, M. Aurousseau, Ciftci R., Burckhart, H., H. K. Hadavand, Prasad, S., A. Lucotte, Plamondon, M, X. Wu, B. Alvarez Gonzalez, Royon, C, J. Ferencei, Vartapetian, A, Buckley, AG, H. Okawa, Derkaoui, J. E., R. Keeler, Ohm, C. C., Uchida, K., S. B. Harpaz, Cantrill, R., A. M. Castaneda Hernandez, Abdallah J, P. Dervan, S. Chekulaev, Hare, G, Labarga, L., Blazek, T., Koutsman, A, Harkusha, S., Meoni, E., Harvey, A., P. Koevesarki, Gallop, BJ, D. Levin, Dube, S., P. Schacht, J. Arguin, Kitamura, T., Knecht, N, Caloba, L, Kogan, L, Clarke, R. N., Tassi, E, Bertin A, Calderini G, Pasqualucci, E., Simoniello, R, Roe, S., C. Friedrich, H. Burckhart, Fiolhais, MCN, S. Panitkin, Tikhomirov, V, Salvatore, D., P. U. E. Onyisi, Garrido, M, B. Osculati, Vuillermet, R, Turra, R., M. S. Neubauer, Oda, S, Cogan, JG, Randrianarivony, K., Klimentov, A., M. Baker, Cowden, C, Brock I., Pagan Griso, S., S. Kabana, Del Peso, J, Rosenberg, EI, Scott, W. G., F. Conventi, Le Dortz, O, Y. Coadou, Kass, R, J. Ginzburg, R. Ciftci, Protopopescu, S, Darbo, G., A. Chitan, C. Haber, Kersevan, BP, R. Alon, Cobal M, Zhu, CG, D. Giugni, P. Vokac, Z. Zhao, Chen S., Antos, J, Rubinskiy, I, Kaczmarska, A, W. Brooks, Gorfine, G, Z. Zhan, Mandelli, L., van der Ster, D, Moore, R. W., Alexa, C, Anulli F, Shao, Q. T., Salvatore, F., S. Crépé-Renaudin, G. Negri, Sanchez Martinez, V., Barbaro Galtieri, A., Bogaerts, J. A., Bugge L., N. Davidson, Kuehn, S., H. Yang, Kantserov, VA, Bhimji W., Kubota, T., Schaile, D., Morettini, P, Nadal, J, Garrido M. D. M. C., Love, P. A., Bucci, F, T. J. Neep, P. Gutierrez, Potter, CJ, Harpaz, S, P. Laycock, K. Sliwa, Stroynowski, R, Romeo, G, Thun, R. P., J-Y. Hostachy, Torregrosa, E, Voss, R., Klinkby, E. B., Hanningerss, GN, Schaffer, AC, D'Auria, S, M. Shiyakova, Ko, B, Hance, M., Mitsui, S., Potter, CT, Yurkewicz, A, Teixeira-Dias, P, G. Alimonti, J. M. Butler, Chelstowska, M.A., Chen H., Sicho, P, Z. Czyczula, Bella, L. Aperio, Clarke, RN, Esch, H, Y. Tayalati, Chiefari, G, Capriotti D, K. Kroeninger, Christidi I. A., Papadelis, A, S. M. Consonni, J. Jia, Martin, JP, Karakostas, K, do Vale, M, S.w. Banerjee, Knecht, N. S., Pennine, B, Ciapetti G, von der Schmitt, H, Leontsinis, S., Boonekamp M, Addy TN, ALOISIO, ALBERTO, M. S. Alam, P. F. Giraud, E. Coniavitis, Anghinolfi F, Chu M. L., Aguilar Saavedra, J, C. Lapoire, Sosebee, M., Lungwitz, M, Lenz, T., Khalek, S, Petschull, D, C. P. Buszello, Huegging, F, Haug, S., Shimojima, M, Bozovic Jelisavcic I, Barreiro F, R. Mandrysch, M. Lassnig, Oakes, L. B., C. Petridou, P. Staroba, Voss, TT, Paleari, C, Wemans, ADV, Abramowicz, H., Ilic, N, Raas, M., Wheeler-Ellis, S. J., Yan, Z., Yasu, Y, A. Olariu, Meng, Z, Ishmukhametov, R., S. Sacerdoti, Tokushuku, K., Haywood, SJ, S. Kalinin, Moreno Llácer, M., Petridis, A., Terada, S., Cristinziani, M, A. Dafinca, Blondel, A., Le Guirriec, E., Head, SJ, Caron, S., Caputo R., Moeser, N, Luijckx, G., Del Papa, C, Smolek, K, K. Nagai, S. Tanaka, Maxfield, S. J., Barlow N, A. E. Barton, Y. S. Gao, E. Devetak, M. Ridel, Esposito, B., Wu, Y., Armbruster, A. J., Badescu, E, K. Ellis, J. A. Wilson, Albert, J., K. Mönig, Chapman, J, Chekanov S., Huettmann, A., Wermes, N., Arik, M, Castaneda-Miranda, E, S. Pashapour, Wu, X., Washbrook, A, Koutsman, A., Matricon, P., C. Malone, D. R. Quarrie, Kortner, S., Yagci, KD, O. Bulekov, A. Coccaro, Ishino, M., D. Dobos, Scannicchio, DA, Borissov G., Arik, E, della Porta, GZ, G. Piacquadio, D. Berge, F. Prokoshin, Torre, H., E. Panagiotopoulou, S. Hamilton, A. Manabe, Venturi, N., Belloni A., Nurse, E, N. Morange, Lassnig, M., Vorwerk, V, Damazio, D, S. Goldfarb, Lohse, T., Brau, B., V. Pozdnyakov, P. Savard, Chekulaev, S, S. Yanush, Lavrijsen, W., T. Rador, P. Steinberg, Curatolo, M, Sjursen, T. B., Dervan, P, J. Stark, M. A. B. do Vale, Krejci, F, Giovannini, P., P. S. Miyagawa, B. Gorini, Cavaliere V, G. Iacobucci, Canale, V, O'Neale, S, Bierwagen, K., Gazis, E, A. A. Solodkov, Fernando, W., Stoicea, G, Smirnov, SY, Quadt, A., Stradling, A. R., Pedis, D., Marzano, F., Lj. Simic, Shimizu, S, Flowerdew, MJ, Eschrich, I, Ciftci R, Shank, JT, A. G. Olchevski, Chakraborty, D, Bolnet, N, Hesketh, G. G., Wiglesworth, C +999 morecore +1 more sourceInterpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more sourceProteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi +10 morewiley +1 more sourceDNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang +14 morewiley +1 more source
