Results 41 to 50 of about 122,580 (304)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
ATLAS Forward Proton Time-of-Flight detectors: status, performance and new physics results
, 2023 ATLAS Forward Proton Time-of-Flight (ToF) detectors of the ATLAS Forward Proton (AFP) system are designed to measure the primary vertex z-position of central exclusive processes by comparing the arrival times measured in the ToF from the two intact ...
Ernani Martins Neto, Daniel +1 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Combined search for the Standard Model Higgs boson in pp collisions at s√=7 TeV with the ATLAS detector [PDF]
, 2012 A combined search for the Standard Model Higgs boson with the ATLAS detector at the LHC is presented. The data sets used correspond to integrated luminosities from 4.6 fb−1 to 4.9 fb−1 of proton-proton collisions collected at s√=7 TeV in 2011.
ATLAS Collaboration
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Scientific AfricanThis study focuses on the application of remote sensing techniques for litho-structural mapping and calcite index detection in the Middle Atlas of Morocco.
Abdelkhiar Ait Ali +7 more
doaj +1 more source
Lithospheric structure in NW of Africa: Case of the Moroccan Atlas Mountains
Geodesy and Geodynamics, 2015 This study presents the outcomes of the local earthquake tomography applied in the Moroccan Atlas domains. A seismic data collected by 36 seismic and a linearized inversion technics are used for determination of local velocity structure.
Youssef Timoulali +3 more
doaj +1 more source
Swiss Journal of Palaeontology, 2023 Ever since the discovery of the first remains of Macrauchenia patachonica by Charles Darwin in 1834, this taxon has puzzled researchers with its peculiar anatomy.
Hans P. Püschel, Agustín G. Martinelli
doaj +1 more source