Results 111 to 120 of about 434,921 (404)

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Differential Features of Culprit Intracranial Atherosclerotic Lesions: A Whole-Brain Vessel Wall Imaging Study in Patients With Acute Ischemic Stroke. [PDF]

, 2018
BackgroundIntracranial atherosclerotic disease tends to affect multiple arterial segments. Using whole-brain vessel wall imaging, we sought to study the differences in plaque features among various types of plaques in patients with a recent unilateral ...
Bi, Xiaoming, Diniz, Marcio A, Fan, Zhaoyang, Gonzalez, Nestor R, Guo, Xiuhai, Ji, Xunming, Li, Debiao, Ma, Qingfeng, Song, Haiqing, Song, Shlee S, WISP Investigators, Wu, Fang, Yang, Qi   +12 more
core  

Mouse Model of Middle Cerebral Artery Occlusion

Journal of Visualized Experiments, 2011
Stroke is the most common fatal neurological disease in the United States 1. The majority of strokes (88%) result from blockage of blood vessels in the brain (ischemic stroke) 2.

semanticscholar   +1 more source

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Advanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu, Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Meng Chen, Yanqi Xu, Bettina Hjelm Clausen, Keshuo Jin, Yiting Lu, Fuqi Mei, Xue Du, Kangmin Chen, Huiyuan Bai, Xian Su, Bincheng Zhou, Baohua Liu, Ran Li, Chaoqun Wang, Yuhua Li, Xiang Cai, Dirk Schlüter, Weihong Song, Xu Wang   +22 more
wiley   +1 more source

Telencephalon vascularity in sheep (Ovis aries)

Pesquisa Veterinária Brasileira
: The studies into the vascularity of the telencephalon in Polish Merino sheep of both sexes were made on 60 cerebral hemispheres. It was found that the middle cerebral artery is the most powerful vessel supplying blood to the telencephalon.
Benedykt Skoczylas, Witold Brudnicki, Krzysztof Kirkiłło-Stacewicz, Włodzimierz Nowicki, Jan Wach   +4 more
doaj   +1 more source

A middle cerebral artery ischemic stroke occurring in a child with a large prolactinoma. [PDF]

, 2020
Pituitary adenomas are rare in children, and often present with symptoms of headache, nausea or emesis, visual disturbance, or hormonal hypersecretion.
Amara, Dominic, Clerkin, Patricia, Gupta, Nalin, Oh, Taemin   +3 more
core  

From time-series to complex networks: Application to the cerebrovascular flow patterns in atrial fibrillation [PDF]

, 2017
A network-based approach is presented to investigate the cerebrovascular flow patterns during atrial fibrillation (AF) with respect to normal sinus rhythm (NSR).
Bastian M., Etchings J. A., Fabio Cazzato, Hayano J., Luca Ridolfi, Newman M. E. J., Saul J. P., Stefania Scarsoglio, Valente T. W., Westerhof N., Yamamoto Y.   +10 more
core   +2 more sources

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Endovascular Therapy for Isolated Cervical Internal Carotid Artery Occlusion

Stroke: Vascular and Interventional Neurology
Background Guidelines on endovascular therapy for acute ischemic stroke do not include isolated cervical internal carotid artery (cICA) occlusions. The effect of treating these lesions remains unclear.
Katrine Falkesgaard, Jakob N. Hedegaard, Jonas Jensen, Thabele M. Leslie‐Mazwi, Rolf A. Blauenfeldt, Claus Z. Simonsen   +5 more
doaj   +1 more source

Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway

Neural Regeneration Research, 2019
Acacetin (5,7-dihydroxy-4′-methoxyflavone), a potential neuroprotective agent, has an inhibitory effect on lipopolysaccharide-induced neuroinflammatory reactions.
Juan Bu, Shen Shi, Hui-Qin Wang, Xiao-Shan Niu, Zong-Feng Zhao, Wei-Dong Wu, Xiao-Ling Zhang, Zhi Ma, Yan-Jun Zhang, Hui Zhang, Yi Zhu   +10 more
doaj   +1 more source