Results 41 to 50 of about 195,466 (218)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

In silico analysis of embolism in cerebral arteries using fluid-structure interaction method

Heliyon
Ischemic stroke, particularly embolic stroke, stands as a significant global contributor to mortality and long-term disabilities. This paper presents a comprehensive simulation of emboli motion through the middle cerebral artery (MCA), a prevalent site ...
Pouria Talebibarmi, Bahman Vahidi, Mahtab Ebad   +2 more
doaj   +1 more source

The cortical branches of the middle cerebral artery in the otter (Lutra lutra)

Veterinární Medicína, 2012
The cortical branches of the middle cerebral artery in the otter were described using 60 hemispheres. It was demonstrated that the artery is divided into ten permanent branches.
B. Skoczylas, W. Brudnicki, W. Nowicki, K. Kirkillo-Stacewicz, R. Jablonski, J. Wach   +5 more
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Application of solitaire double-stent thrombectomy in the treatment of accessory middle cerebral artery occlusion: a case report

Frontiers in Surgery
The accessory middle cerebral artery (AMCA) refers to the cerebral vascular variation originating from the anterior cerebral artery, passing through the lateral fissure and accompanying the middle cerebral artery (MCA), and participating in the blood ...
Qi Han, Guang-Hui Dong, En-Bo Zhu, Ming-Quan Lin, Guang-Lin Liu, Guang-lin Jin, Lin-Zhuo Qu, Hong-Jian Guan, Hui-ying Che   +8 more
doaj   +1 more source

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

Management of pseudoaneurysm and cervical hematoma following carotid sheath placement in a patient with middle cerebral artery thrombosis: a case report

Journal of Medical Case Reports
Background Middle cerebral artery occlusions are present in up to one third of patients with acute ischemic strokes who are undergoing endovascular mechanical thrombectomy, which, especially with intravenous thrombolysis, effectively treats proximal ...
Meghdad Ghasemi Gorji, Rojan Abdollahzadeh Mirali, Yasamin Bigdeli   +2 more
doaj   +1 more source

Neonatal Middle Cerebral Artery Stroke

Pediatric Neurology Briefs, 1995
The presentation, EEG, imaging studies, and outcome of six term neonates with middle cerebral artery infarcts are reported from Mannheim Hospital, University of Heidelberg, Germany.
J Gordon Millichap
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source