The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases
MedComm, Volume 6, Issue 6, June 2025.Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu +7 more
wiley +1 more source
Evaluation of Local Intra-Arterial Fibrinolytic Therapy for Acute Middle Cerebral Artery Occlusion [PDF]
, 2000 S. Tamatani +7 more
openalex +1 more source
Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies
MedComm, Volume 6, Issue 6, June 2025.Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen +6 more
wiley +1 more source
GABAergic contribution to rat bladder hyperactivity following middle cerebral artery occlusion.
, 1999 Sayoko Kanie +4 more
openalex +1 more source
Protective Effect of Endothelin Type A Receptor Antagonist on Brain Edema and Injury After Transient Middle Cerebral Artery Occlusion in Rats [PDF]
, 2001 Yoshiyuki Matsuo +3 more
openalex +1 more source
Mitochondrial Transplantation: A Novel Therapeutic Approach for Treating Diseases
MedComm, Volume 6, Issue 6, June 2025.This article describes the roles of mitochondria in health and disease and reviews the effects of mitochondrial transplantation in disease, including restoring ATP production, attenuating oxidative stress, modulating inflammatory responses, reducing apoptosis, promoting cell repair, and exhibiting antitumor properties.
Xinglu Miao +4 more
wiley +1 more source
Differences in Neurotransmitter Synthesis and Intermediary Metabolism between Glutamatergic and GABAergic Neurons during 4 Hours of Middle Cerebral Artery Occlusion in the Rat: The Role of Astrocytes in Neuronal Survival [PDF]
, 2001 Asta K. Håberg +5 more
openalex +1 more source