Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Mitigating the identity and health threat of COVID-19: Perspectives of middle-class South Asians living in the UK. [PDF]
J Health Psychol, 2022 Hanson K +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Editorial - Erosion of the Middle Class?
sozialpolitik.ch, 2019 Monica Budowski, Sebastian Schief
doaj +1 more source
Lifestyle of Kazakhstan’s middle class in contemporary conditions
Хабаршы. Психология және социология сериясы, 2015 Over the past few years, the political, economic and social situation in Kazakhstan has changed a lot. Kazakhstan has managed to create an enabling environment for private sector development and attracting foreign direct investment, through decisive ...
D. K. Burkhanova
doaj
Willingness to pay for an intervention that reduces soda consumption among a sample of middle-class adult Mexicans. [PDF]
PLoS One, 2021 Colchero MA +4 more
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
"The Internet Is Keeping Me from Dying from Boredom": Understanding the Management and Social Construction of the Self Through Middle-Class Indian Children's Engagement with Digital Technologies During the COVID-19 Lockdown. [PDF]
Int J Child Maltreat, 2022 Sandhu D, Barn R.
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source