Results 161 to 170 of about 2,602,328 (411)

A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse [PDF]

open access: yes, 2016
Acute otitis media, inflammation of the middle ear, is the most common bacterial infection in children and, as a consequence, is the most common reason for antimicrobial prescription to this age group.
Azar, Ali   +10 more
core   +2 more sources

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

open access: yesAdvanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen   +12 more
wiley   +1 more source

Biallelic GTF2IRD1 variants in brothers with profound neurodevelopmental disorder: A possible novel disorder involving a critical gene for Williams syndrome

open access: yesAmerican Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 332-337, February 2023., 2023
Abstract GTF2IRD1, a gene on chromosome 7 which encodes a transcription factor, is of significant clinical interest due to its heterozygous loss as part of the classical deletion associated with Williams–Beuren syndrome (WBS). However, biallelic variants in GTF2IRD1 alone as part of an autosomal recessive disease have not been previously reported. Here,
Christopher Thomas Cummings   +1 more
wiley   +1 more source

The role of KRT5+ progenitors in chronic otitis media [PDF]

open access: yes, 2020
Background: Chronic inflammation of the middle ear, known as chronic otitis media, is a debilitating condition of unknown aetiology that causes hearing loss in children and adults.
Chandrasekharan, Deepak P.
core  

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

open access: yesAdvanced Science, EarlyView.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li   +12 more
wiley   +1 more source

1p36 deletion syndrome: Review and mapping with further characterization of the phenotype, a new cohort of 86 patients

open access: yesAmerican Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 445-458, February 2023., 2023
Abstract Chromosome 1p36 deletion syndrome (1p36DS) is one of the most common terminal deletion syndromes (incidence between 1/5000 and 1/10,000 live births in the American population), due to a heterozygous deletion of part of the short arm of chromosome 1.
Clémence Jacquin   +47 more
wiley   +1 more source

Application of laser autodyne for vibration assessment of tympanic membrane [PDF]

open access: yesСаратовский научно-медицинский журнал, 2011
Research is devoted to assessing the state of the middle ear structures by usage of modern nanotechnology methods. The history of the problem, various ancient and modern methods for studying the mobility of the middle ear structures have been described ...
Skripal A.V.   +4 more
doaj  

Realistic 3D computer model of the gerbil middle ear, featuring accurate morphology of bone and soft tissue structures [PDF]

open access: yesarXiv, 2011
In order to improve realism in middle ear (ME) finite element modeling (FEM), comprehensive and precise morphological data are needed. To date, micro-scale X-ray computed tomography (\mu CT) recordings have been used as geometric input data for FEM models of the ME ossicles.
arxiv  

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