Results 111 to 120 of about 10,488,242 (264)

Enviromics and Abiotic Enviromics: Enhancing Stress Biology and Plant Resilience Breeding

Advanced Science, EarlyView.
Environmental stressors are captured through high‐throughput envirotyping and integrated into an enviromic framework with genomic, transcriptomic, phenomic, and environmental data. AI/ML models enable prediction and guide marker‐assisted selection, genomic selection, genome editing, and gene pyramiding toward improved abiotic stress tolerance, yield ...
Guangchao Sun, Jose Luis Araus, James C. Schnable, Jie Xu, Henry T. Nguyen, Yunbi Xu, Yanli Lu   +6 more
wiley   +1 more source

Association of smoking with hearing loss—a hospital based retrospective case–control study

The Egyptian Journal of Otolaryngology
Background Smoking is known to be a risk factor for several lifestyle diseases ranging from chronic obstructive pulmonary disease to devastating conditions like lung carcinoma. Free radical damage and oxidative stress due to the contents of tobacco smoke
Aishwarya T. Bhatt, Garima Upreti
doaj   +1 more source

Prevalence and Interplay of Modifiable and Genetic Determinants of Eustachian Tube Dysfunction Among Saudi Adults: A Nationwide Study

Diagnostics
Background/Objectives: Eustachian Tube Dysfunction (ETD) is a prevalent condition affecting middle ear pressure regulation, yet nationwide epidemiological data in Saudi Arabia remain limited.
Mohammad A. Jareebi, Riyadh A. Jahlan, Abdulrahman A. Otaif, Abdulelah A. Otaif, Abdulrahman A. Daghreeri, Mashael S. Mahnashi, Raghad W. Al Nahwe, Yahya A. Maslamani, Ali Y. Mashragi, Abdullah Mawkili, Wedad Mawkili, Faisal Hakami, Sulaiman Ahmed Hussain Darbashi, Majed A. Ryani, Ahmed A. Bahri   +14 more
doaj   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Preoperative Predictors of round window visibility on High resolution CT-scan temporal bone in patients undergoing cochlear implant surgery: A Systematic Review

Journal of the Pakistan Medical Association
Objective: To evaluate the correlation of high-resolution computed tomography-based radiological predictors with the surgical ease of access to the round window membrane in cochlear implant surgery.
Syed Akbar Abbas, Muhammad Wasif, Abdul Basit Shah Vardag, Haissan Iftikhar, Huzaifa Moiz, Syed Shabbir Afzal   +5 more
doaj   +1 more source

Osseoperceptive EMG Feedback Improves Grasp Force Control in Myoelectric Prosthetic Hands

Advanced Science, EarlyView.
Osseoperception is explored as a non‐invasive pathway for delivering sensory feedback in myoelectric prosthetic control. By encoding the user's electromyographic (EMG) signal through bone‐conducted stimulation, this approach enables predictive grasp force regulation.
Cristian Felipe Blanco‐Diaz, Strahinja Dosen, Leonardo Cappello   +2 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Middle Ear Risk Index (MERI) as a Prognostic Factor in Tympanoplasty in Chronic Otitis Media

Background: Otologic surgery is complicated by middle ear pathology, which often causes surgical results in Chronic Otitis Media to vary. Middle Ear Risk Index is a new surgical risk variable stratification and tympanoplasty prediction tool. Methods: Nalanda Medical College and Hospital in Patna, India, investigated if MERI could predict tympanoplasty ...
Sweta Sinha, Paritosh Kumar, Viddya Nand Pal   +2 more
openaire   +2 more sources

Non-invasive assessment of bacterial biofilm in the middle ear using low-coherence interferometry/optical coherence tomography and acoustic measurements [PDF]

, 2012
Otitis media (OM) is a middle ear infection caused by bacterial growth between the tympanic membrane (TM) and the inner ear. Children with chronic OM, including OM with effusion and recurrent OM, often have conductive hearing loss and communication ...
Nguyen, Cac
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