Results 101 to 110 of about 10,488,242 (264)

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Risk factors for Australian school-age children in socio-economically disadvantaged populations not passing ear and hearing screening

, 2021
Objectives and importance of study: The consequences of sensorineural hearing loss in young children include poor speech and language development, poor educational outcomes,and delayed socio-emotional development.
Catherine M McMahon, Jade McLennan, Neil J Orr, Kai Nash, Phillip Nakad   +4 more
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Is body mass index before middle age related to coronary heart disease risk in later life? [PDF]

, 2009
Objective: Although obesity beginning early in life is becoming more common, its implications for coronary heart disease (CHD) risk in later life remain uncertain.
Orfei, L, Osmond, C, Owen, C.G., Cook DG, Whincup, PH, Whincup, P.H., Rudnicka, A.R., Osmond C, A K Wathern, Chou, QA, Eriksson, JG, L Orfei, Eriksson, J.G., C Osmond, Kaye, SJ, D G Cook, Kaye, S.J., Wathern AK, C G Owen, Q-A Chou, Kaye SJ, J G Eriksson, Rudnicka, AR, Wathern, AK, A R Rudnicka, Rudnicka AR, Owen CG, Chou QA, Whincup PH, Eriksson JG, Wathern, A.K., Orfei L, S J Kaye, Cook, D.G., Chou, Q-A., Owen, CG, Cook, DG, P H Whincup, Osmond, C., Orfel, L.   +39 more
core   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Middle Ear Risk Index e resultados da timpanoplastia pediátrica Preditor adequado?

, 2023
Resumo Objetivos: Determinar a utilidade do Middle Ear Risk Index (MERI) como preditor de sucesso da timpanoplastia na população pediátrica. Material e Métodos: Estudo retrospetivo das crianças (idade inferior a 18 anos) que foram submetidas a timpanoplastia entre 2014 e 2021. Foram recolhidos dados demográficos e dados clínicos referentes ao estado do
Carção,André Alves, Gomes,Pedro Marques, Cunha-Cabral,Diogo, Duarte,Delfim, Neves,Marta   +4 more
openaire   +1 more source

Radiologic anatomy of the middle ear and internal ear in computed tomography images [PDF]

, 2023
The development of imaging methods that has taken place in the last twenty years and the increase in the availability of highresolution CT of temporal bones makes it possible to analyze the complex anatomy of the interior of temporal bone in detail with ...
Wojciechowski, Tomasz
core  

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source