SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source
Middle East Respiratory Syndrome Coronavirus Could be a Priority Pathogen to Cause Public Health Emergency: Noticeable Features and Counteractive Measures. [PDF]
Chandran D +9 more
europepmc +1 more source
Abstract This study investigates the claim that women are disproportionately more likely to die in disasters by reviewing existing data sources and compiling new datasets on sex‐differentiated disaster fatalities in the twenty‐first century. The analysis is structured by disaster type, covering geophysical, meteorological, climatological, hydrological,
Olivier Rubin
wiley +1 more source
Improving risk analysis of the environmental drivers of the spillover, emergence/re-emergence and spread of Crimean-Congo haemorrhagic fever virus, Marburg virus and Middle East respiratory syndrome coronavirus in the East Africa Region. [PDF]
Ajumobi O +6 more
europepmc +1 more source
Novel MYL1 Intron Variant With Expanded Phenotype
ABSTRACT Congenital myopathy‐14 (CMYO14) is an ultrarare autosomal recessive disorder caused by biallelic variants in MYL1, with only four patients reported to date. We describe what is likely the fifth reported patient, a neonate with severe hypotonia, respiratory insufficiency, and skeletal anomalies showing distinct histological changes of skeletal ...
Maria Barington +7 more
wiley +1 more source
Spatial examination of social and environmental drivers of Middle East respiratory syndrome coronavirus (MERS-CoV) across Kenya. [PDF]
Lawrence TJ +7 more
europepmc +1 more source
Subterranean environments contribute to three‐quarters of classified ecosystem services
ABSTRACT Beneath the Earth's surface lies a network of interconnected caves, voids, and systems of fissures forming in rocks of sedimentary, igneous, or metamorphic origin. Although largely inaccessible to humans, this hidden realm supports and regulates services critical to ecological health and human well‐being.
Stefano Mammola +30 more
wiley +1 more source
Identification of a Spike-Specific CD8+ T-Cell Epitope Following Vaccination Against the Middle East Respiratory Syndrome Coronavirus in Humans. [PDF]
Harrer CE +11 more
europepmc +1 more source
To Mars through LEO: How commercial space travel will change exploration‐enabling research
Experimental Physiology, EarlyView.
Christopher Puhl, Michail Magkos
wiley +1 more source
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra +4 more
wiley +1 more source

