Results 61 to 70 of about 2,093,888 (302)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

“When That Wounds Are Evil Healed”: Revisiting Pleonastic That in Early English Medical Writing

Studia Anglica Posnaniensia, 2017
The origin of pleonastic that can be traced back to Old English, where it could appear in syntactic constructions consisting of a preposition + a demonstrative pronoun (i.e., for py pat, for pæm pe) or a subordinator (i.e., op pat). The diffusion of this
Martín Javier Calle
doaj   +1 more source

Brotherton Collection MS 501 : a Middle English anthology reconsidered [PDF]

, 1990
Brotherton Collection MS 501, in Leeds University Library, is a fifteenth-century anthology of Middle English religious verse and prose, best known for the Prick of Conscience with which it begins.
Pickering, O.S.
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Some Observations on the First Middle English Translation of the Revelation of John

Filologia Germanica
The Revelation of John represents one of the most popular texts of medieval Europe. This popularity, undoubtedly fuelled by fears and expectations of the year one thousand, is reflected not only in the presence of millenarian themes in contemporary ...
Letizia Vezzosi
doaj   +1 more source

The Status of Old English Dare Revisited

Studia Anglica Posnaniensia, 2017
The development of dare in the history of English has played an important role in the literature on grammatical change and (de)grammaticalization. This paper aims to clarify two issues regarding the syntax and semantics of dare in earlier English: when ...
Gregersen Sune
doaj   +1 more source

Spiritual writings and religious instruction [PDF]

, 2008
As soon as a would-be writer picked up the pen in this period, he (or just occasionally she) had to make a far-reaching decision: whether to write in English, Anglo-Norman or Latin. The answer would emerge from the intersection of the text's genre and of
Barratt, Alexandra
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The Dynamics of Postnominal Adjectives in Middle English

Anglica. An International Journal of English Studies, 2022
Middle English was a period of transition between the free word order of Old English, with functional variation of adjective form and position with respect to the head noun, and the fixed prenominal placement of single attributive adjectives in Modern ...
Veronika Volná, Pavlína Šaldová
doaj   +1 more source