Results 141 to 150 of about 258,952 (290)

On the stress-sum index of the middle and central graph of a graph

Boletim da Sociedade Paranaense de Matemática
Ranking molecular chemical compounds or large networks is a complex task due to their inherent degeneracy. Centrality measures helps to estimate the rank of each molecular chemical graph. One such centrality measure is the stress centrality, which quantifies the number of shortest paths passing through a given vertex.
null Niveditha, K. Arathi Bhat, Shahistha Hanif   +2 more
openaire   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Dual-graph attention autoencoder for spatial domain identification in ischemic stroke

Frontiers in Neuroscience
IntroductionSpatial transcriptomics enables molecular mapping of ischemic stroke tissue, but spatial domain identification is challenging when injury disrupts normal tissue geometry.
Yuan-Yuan Chen, Yuan-Yuan Chen, Wang-Ting Hu, Gang Zhang, Xian-Liang Rao, Tao Jiang   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

1:250,000 South Levant / [PDF]

, 1943
Map series of northern Israel, Jordan and northwest Saudi Arabia showing grid, international and administrative boundaries, railways, roads (2 categories), tracks, telegraph lines, oil pipe lines. Relief shown variously as contours (interval 100 metres),
Great Britain. Army. Royal Engineers. Field Survey Company, 514, cartographer. issuing body.
core  

The social–ecological model of depressive symptoms in middle aged in China: a network analysis

BMC Public Health
Background Depression in middle-aged individuals is influenced by multiple factors; however, research focusing on this demographic remains limited. The social-ecological system framework explores how interactions among individual characteristics, social ...
Guanghui Shen, Yu-Hsin Chen, Yang Zou, Shaochang Wu, Yawen Zheng, Li Chen   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Partial domination of middle graphs

For any graph $G=(V,E)$, a subset $S\subseteq V$ is called {\it an isolating set} of $G$ if $V\setminus N_G[S]$ is an independent set of $G$, where $N_G[S]=S\cup N_G(S)$, and {\it the isolation number} of $G$, denoted by $ι(G)$, is the size of a smallest isolating set of $G$. In this article, we show that the isolation number of the middle graph of $G$
Zhang, Shumin, Li, Minhui, Dong, Fengming   +2 more
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source