Results 131 to 140 of about 2,650,610 (297)
Causal reasoning and symbolic relationships in Medieval Illuminations Raisonnement causale et relations symboliques dans les Enluminures médiévales [PDF]
Journal of Data Mining and Digital Humanities, 2019 This work applies knowledge engineering’s techniques to medieval illuminations. Inside it, an illumination is considered as a knowledge graph which was used by some elites in the Middle Ages to represent themselves as a social group and exhibit the ...
Djibril Diarra +2 more
doaj
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
HOW IS THE EUROPEAN UNION SECURITIZING CLIMATE CHANGE IN THE MIDDLE EAST? [PDF]
This thesis examines the complex relationship between climate change and regional instability in the Middle East and North Africa (MENA), by focusing on Syria, and assesses the European Union's approach to this nexus.
Furtun, Şakire
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
, 2022 The annual publication of the students of G.S. Lakie Middle School, Lethbridge, Alberta. (2018-19)pdfG.S. LAKIE Middle School Lethbridge, Alberta ■ - ■ ■ - ; 7 before construction .. ...... Published in Canada Printed in USA •••• 1 The Honourable Ty Lund,
G.S. Lakie Middle School
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Çin'in Körfez'deki Enerji Güvenliği
, 2023 China became the world's largest net oil importer in 2013; half of this oil comes from the Middle East, and about 30% comes from the Gulf countries. Despite efforts to diversify its energy use, China is expected to import more oil from the Middle East ...
Yoncacı, Alperen
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source