Results 131 to 140 of about 2,773,301 (295)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

CONTACT ANALYSIS OF THE SPIRAL BEVEL GEAR BASED ON MATLAB

Jixie qiangdu, 2016
In this paper,the use of local synthesis method,study the tooth contact analysis（ TCA） of the CRH5 traction gear by programming with MATLAB,respectively,calculate contact tracing line on the tooth surface and the graph of the transmission error of the ...
DONG ShuJing
doaj  

Causal reasoning and symbolic relationships in Medieval Illuminations Raisonnement causale et relations symboliques dans les Enluminures médiévales [PDF]

Journal of Data Mining and Digital Humanities, 2019
This work applies knowledge engineering’s techniques to medieval illuminations. Inside it, an illumination is considered as a knowledge graph which was used by some elites in the Middle Ages to represent themselves as a social group and exhibit the ...
Djibril Diarra, Martine Clouzot, Christophe Nicolle   +2 more
doaj  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Equitable Coloring on Triple Star Graph Families

, 2018
An equitable k-coloring of a graph G is a proper k-coloring of G such that the sizes of any two color class differ by at most one. In this paper we investigate the equitable chromatic number for the Central graph, Middle graph, Total graph and Line graph
M. Venkatachalam (5758480), K. Praveena (595776)   +1 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

On the stress-sum index of the middle and central graph of a graph

Boletim da Sociedade Paranaense de Matemática
Ranking molecular chemical compounds or large networks is a complex task due to their inherent degeneracy. Centrality measures helps to estimate the rank of each molecular chemical graph. One such centrality measure is the stress centrality, which quantifies the number of shortest paths passing through a given vertex.
null Niveditha, K. Arathi Bhat, Shahistha Hanif   +2 more
openaire   +1 more source