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Developing Mathematics Enrichment Workshops for Middle School Students: Philosophy and Sample Workshops [PDF]
, 1997 This paper describes our approach to organizing enrichment activities using advanced mathematics topics for diverse audiences of middle school students.
Keynes, H., Olson, A., Singer, K.
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
On Two Ways of Enumerating Ordered Trees
, 2021 The middle-levels graph $M_k ...
Dejter, Italo J.
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Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
PLoS ONE, 2022 This study attempted to answer the question, "Can filtering the functional data through the frequency bands of the structural graph provide data with valuable features which are not valuable in unfiltered data"?.
Alireza Talesh Jafadideh +1 more
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Phases of tree-decorated Dynamical Triangulations in 3D
Journal of High Energy PhysicsThis work revisits the Euclidean Dynamical Triangulation (DT) approach to non-perturbative quantum gravity in three dimensions. Inspired by a recent combinatorial study [1] of a subclass of 3-sphere triangulations constructed from trees, called the ...
Timothy Budd, Dániel Németh
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Partial domination of middle graphs
For any graph $G=(V,E)$, a subset $S\subseteq V$ is called {\it an isolating set} of $G$ if $V\setminus N_G[S]$ is an independent set of $G$, where $N_G[S]=S\cup N_G(S)$, and {\it the isolation number} of $G$, denoted by $ι(G)$, is the size of a smallest isolating set of $G$. In this article, we show that the isolation number of the middle graph of $G$
Zhang, Shumin +2 more
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