Results 51 to 60 of about 297,749 (354)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The impact of business intelligence and digital supply chain capabilities on sustainable supply chain performance in Jordanian industrial companies: the mediating role of operational efficiency

open access: yesHeritage and Sustainable Development
The growing pressure of industrial companies to improve their sustainability performance increased the necessity of digital-oriented transformation of the supply chain. The proposed research considers the role of business intelligence and digital supply
Tamara Adel Al-maaitah   +5 more
doaj   +1 more source

The World of Middle Kingdom III: Contributions on Archaeology, Art, Religion, and Written Sources

open access: yes, 2022
The volume includes 22 articles on the Middle Kingdom and Second Intermediate Period, ranging from archaeological finds to written sources, from prosopography to landscape studies.
Grajetzki, WOLFRAM RUEDIGER   +2 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

The Middle Kingdom and the Dharma Wheel : aspects of the relationship between the Buddhist Saṃgha and the state in Chinese history /

open access: yes
The matter of saá¹gha-state relations is of central importance to both the political and the religious history of China. The volume The Middle Kingdom and the Dharma Wheel brings together, for the first time, articles relating to this field covering a ...
JuÌlch, Thomas.
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Exploratory palynological studies at the Tell el-Daba'a-Avaris archaeological site.

open access: yesPLoS ONE, 2018
A palynological study of samples collected from the Tell el-Daba'a (Avaris) archaeological site, the capital of the Hyksos located in the Northeastern Nile Delta, Egypt, was conducted.
Mohamed F Azzazy, Mohamed F Azzazy
doaj   +1 more source

Ritual Marriage Alliances and Consolidation of Power in Middle Egypt during the Middle Kingdom

open access: yesÉtudes et Travaux (Institute des Cultures Méditerranéennes et Orientales de l'Académie Polonaise des Sciences), 2017
Middle Egypt is the most fertile region in the country and its provincial governors were the richest and most powerful. Intermarriages between members of neighbouring nomarchic families created a strong power base, resulting in most governors gradually ...
Naguib Kanawati
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Miniaturized Inset-Fed Microstrip Patch Sensor Based on Meander-Line Slot for Water Measurement Applications

open access: yesJournal of Techniques
This article introduces a high-sensitive microstrip-patch sensor-based meander-line slot structure for water measurement applications. The HFSS software tool is employed to design and simulate the proposed system.
Aya Khalid Hadi   +2 more
doaj   +1 more source

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