Results 121 to 130 of about 17,248,021 (313)

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Awareness of prostate cancer and its screening tests in men in the Middle East: A systematic review and meta-analysis

Journal of Family and Community Medicine
Prostate cancer (PCa) is a significant health issue characterized by the uncontrolled growth of cells in the prostate gland primarily affecting men 50 years old or older.
Nawaf S.A. Mohamed, Joud M.O. Asfari, Samar M.A. Sambawa, Rima M.D. Aljurf, Kholoud A.A. Alsaygh, Assad M. Arafah   +5 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

«Allora Maria prenderà il tamburello e animerà alla danza le vergini ». Paradigmi femminili di danza e conoscenza al cristianesimo

Storia delle Donne
This article analyses dance as a language of knowledge and power in late antique and medieval Christianity, focusing on women’s bodies as mediators between grace and disrepute. From the earliest biblical interpretations, dance emerged as both an inspired
Donatella Tronca
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Awareness of Menopause and its Associated Factors among Men in Eastern India

Journal of Mid-Life Health
Introduction: A menopausal transition is a stressful event in a woman’s life affecting health and quality of life. Spousal awareness of menopausal changes can help them support their wives in coping with the menopausal transition.
Smitha Moonjelly Vijayan, Malini Digal, Sadrita Misra, Riya Pan, Renu, Rushali Gajbhiye, Rikta Manna   +6 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Knowledge And Attitude Towards Menopause In Middle Aged Pakistani Women

Pakistan Journal of Medicine and Dentistry
Background: Menopause lead to changes in women’s physiological functioning. It has significant physical, mental, social and psychological impact on women’s life.
Rehana Yasmeen, Rubina Hussain, Shama Chaudhry, Aliya Waheed   +3 more
doaj