Results 71 to 80 of about 17,248,021 (313)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Middle East Respiratory Syndrome (MERS): Comparing the knowledge, attitude and practices of different health care workers

Journal of Infection and Public Health, 2019
Background Middle East Respiratory Syndrome (MERS) is a viral respiratory illness that was recently recognized in humans. Recently, the Ministry of Health in Saudi Arabia reported a substantial increase in MERS cases, primarily from the Riyadh region ...
A. Albarrak, Rafiuddin Mohammed, Ali Al Elayan, Feras Al Fawaz, Musab Al Masry, Mohammed Al Shammari, Saud Bin Miaygil   +6 more
semanticscholar   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

HOW IS THE EUROPEAN UNION SECURITIZING CLIMATE CHANGE IN THE MIDDLE EAST? [PDF]

This thesis examines the complex relationship between climate change and regional instability in the Middle East and North Africa (MENA), by focusing on Syria, and assesses the European Union's approach to this nexus.
Furtun, Şakire
core  

Enhancement and optimization of a graphene-based biosensing platform using machine learning for precise breast cancer detection

Scientific Reports
In this study, we introduce a machine learning optimized graphene-based biosensor tailored for the early and accurate detection of breast cancer, aiming to elevate diagnostic reliability and clinical efficacy.
Ammar Armghan, Aymen Flah, Sultan S. Aldkeelalah, Mohammad Ghatasheh, Rzgar Farooq Rashid, Naim Ben Ali   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The construction of Middle Eastern museology in the context of power–knowledge relationship [PDF]

Muzeológia a Kultúrne Dedičstvo
The museum has been an important instrument in the construction of the past since the nineteenth century. It has been a symbol of modernization as an institution built in all capitals in Europe from the nineteenth century.
Oytun Doğan
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Local Ecological Knowledge on Climate Change and Ecosystem-Based Adaptation Strategies Promote Resilience in the Middle Zambezi Biosphere Reserve, Zimbabwe

Scientifica, 2019
Understanding local community perceptions on impacts, causes, and responses to climate change is vital for promotion of community resilience towards climate change. This study explored local ecological knowledge (LEK) held by local communities on climate
O. L. Kupika, E. Gandiwa, G. Nhamo, S. Kativu   +3 more
semanticscholar   +1 more source