Results 81 to 90 of about 17,248,021 (313)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
“MIDDLE KNOWLEDGE”: SOLUTION OR SEDUCTION?
UNIO CUM CHRISTO, 2018 In this article, Henri Blocher examines the status and function of “middle knowledge,” a proposed median between determinism and indeterminism, and one that satisfies our natural aspirations to freedom. The theses of Molina and Suarez in particular are carefully presented and evaluated, with reference to the thought of one of their recent capable ...
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Evolution, Middle Knowledge, and Theodicy
Forum Philosophicum, 2020 In this paper, I investigate the relationship between a nonlapsarian, evolutionary account of the origin of sin and the potential ramifications this might have for theodicy. I begin by reviving an early twentieth century evolutionary model of the origin of sin before discussing the most prominent objection which it elicits, namely, that if sin is ...
openaire +1 more source
BMC Health Services Research, 2018 BackgroundAdolescents face significant barriers to contraception access and utilization that result in adverse health effects of early pregnancy and childbirth.
Margaret Munakampe, J. Zulu, C. Michelo
semanticscholar +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
EnergiesThis study provides a comprehensive evaluation of waste-to-energy (WtE) technologies in Saudi Arabia, focusing on municipal solid waste (MSW) across various cities, in alignment with Saudi Vision 2030. Saudi Arabia generates approximately 16 million tons
Mohammed F. M. Abushammala +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Social Sciences, 2018 Previous quantitative research examining Disney movies has highlighted that whilst prince characters display largely balanced gender profiles, princesses exhibit biased gender role portrayals—performing mostly feminine characteristics, rarely ...
Benjamin Hine +4 more
doaj +1 more source
Knowledge and Willingness for Organ Donation in the Middle Eastern Region: A Meta-analysis
Journal of religion and health, 2019 Medical advancements over the past decades brought organ transplantation as a definitive therapy for different end-stage organ failure. However, non-availability of organs required for transplantation is a major challenge worldwide. We aimed to determine
Ahammed Mekkodathil +4 more
semanticscholar +1 more source