Results 111 to 120 of about 4,288,113 (308)

Moving from Inaction to Action: Challenging Homo- and Transphobia in Middle School English Language Arts [PDF]

open access: yes, 2020
What happens when teachers have opportunities to engage in LGBTQ-affirming practices but choose not to? In the following paper, the authors present a vignette from a middle school context and consider ways to challenge silences to support LGBTQ students ...
Colantonio-Yurko, Kathleen   +4 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Volcanic Aerosols Bookmark [PDF]

open access: yes, 2005
This bookmark on volcanic aerosols provides a Web address for additional information and resources.

core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Middle School Elvish

open access: yes, 2018
Heidi: I learned Elvish too like Madi. Me: Really?? Heidi: Yeah [All laughing] Me: how did you get into that? [laughs] Where the heck did elvish come from? Heidi: I was in like middle school and we’d just speak a bit in my friend group. Everyone did it. Me: How do you speak it?
openaire   +2 more sources

Policing and Middle School: An Evaluation of a Statewide School Resource Officer Policy [PDF]

open access: yes, 2018
This study investigates the effectiveness of North Carolina Senate Bill 402, Section 8.36 – Grants for School Resource Officers in Elementary and Middle Schools, which provides matching state funds to districts for use in middle and elementary schools ...
Anderson, Kenneth Alonzo
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Space Math: Solar Storms and You! Exploring Satellite Design [PDF]

open access: yes, 2000
This educator’s guide includes activities in space science.
Sten Odenwald
core  

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