Results 111 to 120 of about 1,402,768 (260)

L1 and L2 Contributions to English Reading in Middle School Struggling Readers. [PDF]

open access: yesBiling (Camb Engl)
Cirino PT   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Investigation on the Attitude of Middle School Students with Depression in the City Toward Professional Psychological Help-Seeking

open access: yesPatient Preference and Adherence
Na Yong,1 Yu-Ling Ren,2 Chun-Yuan Wang,3 Cong Yang4 1Mental Health Center, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, People’s Republic of China; 2Gao Ping Middle School, Nanchong, Sichuan, 637000, People’s ...
Yong N, Ren YL, Wang CY, Yang C
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Humanizing Rational Numbers in Middle School

open access: yesInternational Dialogues on Education: Past and Present
The goal of this paper is to re-examine the curricular framework of math education, particularly around rational numbers in early middle school. Through an exploration of math achievement data, research on successful organizations and systems, research ...
Connor Desai
doaj   +2 more sources

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

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