Results 81 to 90 of about 64,231 (297)

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Simulation workshops with first year midwifery students [PDF]

, 2016
Simulated teaching methods enable a safe learning environment that are structured, constructive and reflective. We prepared a 2-day simulation project to help prepare students for their first clinical practice.
Fox, D., Sheehan, A., Cummins, Allison, Fox, Deborah, Hogan, R, Cummins, A., Fox, D, Cummins, A, Sheehan, A, Catling, Christine J., Hogan, R., Hogan, Rosemarie, Sheehan, Athena (R16653), Catling, C., Kelly, M, Catling, C, Kelly, Michelle   +16 more
core   +1 more source

Renal IGFBP6 Interacts With THBS1 to Drive Renal Cellular Senescence and Fibrosis

Advanced Science, EarlyView.
ABSTRACT Epithelial dedifferentiation and myofibroblast activation are critical drivers of chronic kidney disease (CKD) progression. Elevated levels of IGFBP6 have been linked to decreased renal function in CKD patients, but its precise role and underlying mechanisms remain unclear.
Ju‐tao Yu, Chang‐geng Xu, Xiao‐wei Hu, Run‐run Shan, Jia‐nan Wang, Xiang‐yu Li, Yu‐qing Wang, Yu‐hang Dong, Shen‐Zhuo‐Fan Huang, Shuai Sun, Tian Zhao, Ya‐Xin Ru, Xiao‐yu Shen, Rui Hou, Jian‐min You, Fei Zhang, Chao Li, Jie Wei, Chao Hou, Zhi‐juan Wang, Dan‐feng Zhang, Juan Jin, Jia‐gen Wen, Yu‐jie Liu, Ming‐ming Liu, Xiao‐ming Meng, Wei Wang   +26 more
wiley   +1 more source

Mentorship from the student perspective

, 2014
Midwifery Basics: Mentorship 3 When undertaking a programme of pre-registration midwifery education, student midwives are working towards responsible and accountable practice at the point of registration.
Linford, Dawn, Marshall, Joyce
core  

Establishing midwifery in low-resource settings: Guidance from a mixed-methods evaluation of the Afghanistan midwifery education program

, 2014
© 2013 Elsevier Ltd. Background: the shortage of skilled birth attendants has been a key factor in the high maternal and newborn mortality in Afghanistan.
Azfar, P, Bartlett, L, Zainullah, P, Ansari, N, Kim, YM, Gubin, R, Turkmani, S, LeFevre, A, Azimi, M, Mungia, J, Yari, K   +10 more
core   +1 more source

The impact of pre-registration education on the motivation and preparation of midwifery students to work in continuity of midwifery care: An integrative review

, 2020
Access to continuity of midwifery care (CoMC) models in Australia is increasing but the capacity of the emerging midwifery workforce to provide this care remains largely unknown.
Sidebotham, Mary, Carter, Joanne, Dietsch, Elaine   +2 more
core   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Public health education for midwives and midwifery students: a mixed methods study

BMC Pregnancy and Childbirth, 2012
Background Current national and international maternity policy supports the importance of addressing public health goals and investing in early years. Health care providers for women during the reproductive and early postnatal period have the opportunity
McNeill Jenny, Doran Jackie, Lynn Fiona, Anderson Gail, Alderdice Fiona   +4 more
doaj   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Is one midwife per birthing mother an achievable goal? Education and leadership pathways for midwifery models of care in the Middle East

Frontiers in Global Women's Health
Midwifery models of care (MoC), where midwives are the primary, continuous care providers across pregnancy, labor and the early postnatal period, are central to World Health Organization (WHO) guidance and are associated with fewer interventions and ...
Atika Khalaf, Atika Khalaf
doaj   +1 more source