Results 131 to 140 of about 44,246 (295)

Peptide Fingerprinting of Single Protein Molecules Using In‐Plane Nanopore Sensors Integrated to an Extended Immobilized Nanoscale Enzymatic Reactor (eINER)

Small Methods, EarlyView.
The protein Time‐of‐Flight (P‐ToF) chip can peptide fingerprint a single protein molecule by subjecting it to a solid phase endopeptidase cleavage reaction in‐line with a combination of resistive pulse sensing of the resulting single peptides and machine‐learning aided identification.
Suresh Shivanka, Randy F. Espinal Cabrera, Maximillian Chibuike, Pramodi Vithanage, Indu A. Chandrasoma, Pubudu Premarathne, Matthew Verber, Steven A. Soper   +7 more
wiley   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Evaluation of MIF Projects: Environment

, 2013
This report (MIF/GN-78-13) is the outcome of evaluation of a group of 17 MIF environment projects, as part of the work program of the Office of Evaluation and Oversight (OVE) to evaluate MIF activities, following the mandate of its Donors Committee.
Inter-American Development Bank (IDB), Banco Interamericano de Desarrollo (BID), Banque Interaméricaine de Développement (BID), Banco Interamericano de Desenvolvimento (BID)   +3 more
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Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

Prognostic Value of FST and Relevance to Immune Infiltration in Head and Neck Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Immunotherapy response rates in head and neck squamous cell carcinoma (HNSCC) are limited by multiple factors. Tumor cell‐derived follistatin (FST) has been linked to immunotherapy resistance, but the underlying mechanisms remain poorly understood. This study aimed to investigate the prognostic value of FST and its associations with
Pan Song, Tao‐Wei Wu, Jing‐Yi Wang, Yu‐Chu Ye, Fa‐ya Liang, Xiao‐Ming Huang, Ping Han   +6 more
wiley   +1 more source

Graph neural network‐based attack prediction for communication‐based train control systems

CAAI Transactions on Intelligence Technology, EarlyView.
Abstract The Advanced Persistent Threats (APTs) have emerged as one of the key security challenges to industrial control systems. APTs are complex multi‐step attacks, and they are naturally diverse and complex. Therefore, it is important to comprehend the behaviour of APT attackers and anticipate the upcoming attack actions.
Junyi Zhao, Tao Tang, Bing Bu, Qichang Li   +3 more
wiley   +1 more source

Post‐Breach Events, Itemisation and the Avoided Loss Rule

The Modern Law Review, EarlyView.
In English law, the following equation is used to compute damages awards: (a) loss sustained in consequence of the breach of duty (‘prima facie loss’) minus (b) benefits obtained as a result of the breach of duty = (c) net loss. This paper explores the manner in which prima facie loss is defined.
Melody Hadfield
wiley   +1 more source

Single‐Cell Profiling Links T‐Cell Accumulation and TH2/TH17 Dynamics to Eosinophilic Esophagitis (EoE) Activity in Children

Allergy, EarlyView.
Active EoE is associated with more and deeper epithelial eosinophil, mast cell, and T cell infiltration; inactive EoE resembles controls. During remission, PPI treatment leaves more tissue resident CD3+ T‐cells than TS. In active EoE, TH2 cells, IL‐10hi Tregs, and CD8+ cytotoxic T cells are enriched, while TH17 cells are relatively depleted.
Hannes Hoelz, Matthias Tobias Warkotsch, Simon Buehler, Tim Faro, Sabrina Wagner, Valeriia Andrieieva, Alisia Beckmann, Anja Jurk, Marie‐Luise Frank, Guido Piontek, Kolja Siebert, Sebastian Jarosch, Sibylle Koletzko, Helga Paula Török, Christoph Walz, Martina Rudelius, Katja Steiger, Dirk Busch, Tobias Schwerd   +18 more
wiley   +1 more source

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source

Periodontitisli bireylerde MİF-173 G/C polimorfizmi ile dişeti dokusundaki MİF ekspresyonunun saptanması:|bCerrahisiz periodontal tedaviye ek olarak kullanılan azitromisinin DOS MİF düzeyi üzerine etkisinin araştırılması

, 2009
Periodontitisli Bireylerde MİF-173 G/C Polimorfizmi ile Diseti Dokusundaki MİF Ekspresyonunun Saptanması: Cerrahisiz Periodontal Tedaviye Ek Olarak Kullanılan Azitromisinin DOS MİF Düzeyi Üzerine Etkisinin Arastırılması.
(Han) Sayğan, Buket
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