Results 121 to 130 of about 44,246 (295)

The Combination of circEPSTI1 and MIF Offers Diagnostic Value for Endometrial Cancer

International Journal of General Medicine
Zhili Cui,1 Liyuan Zhou,1 Xin An,2 Wenli Liu,1 Jingxia Li,1 Yueping Zhang,3 Wei Zhang4 1Department of Gynecology, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei, 056002, People’s Republic of China; 2Department of Pathology, Handan ...
Cui Z, Zhou L, An X, Liu W, Li J, Zhang Y, Zhang W   +6 more
doaj  

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Placebo Effect in Levodopa‐Induced Dyskinesia: A Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Levodopa‐induced dyskinesia (LID) is a complication of Parkinson's disease (PD) treatment. While the placebo effect is a known component in PD clinical trials, its specific magnitude in the context of LID is not well characterized.
Luiz Vinicius Silva Correa, Alexandre Martins do Nascimento, Bruno Lopes Santos‐Lobato, Henry Mauricio Chaparro‐Solano, Ignacio Fernandez Mata, Vitor Tumas   +5 more
wiley   +1 more source

Disrupted joint clock is associated with rhythmic expression of bone destruction factors in collagen‐induced arthritis

Rheumatology &Autoimmunity, EarlyView.
Schematic Summary of Circadian Dysregulation in Arthritic Joints. This graphical abstract illustrates the key circadian disruptions observed in the collagen‑induced arthritis (CIA) model. The diagram depicts three main findings: (1) Nocturnal elevations in pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑17, IL‑1β, MIF) and bone‑destructive factors (DKK‑1 ...
Xiaogang Zhang, Mingming Zhang, Zhiqiang Wang, Jie Bai, Xing Feng, Yajing Wang, Zhenbin Li, Dongbao Zhao   +7 more
wiley   +1 more source

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, EarlyView.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

Ultrasensitive MicroRNA Detection Combining Reduced Graphene Oxide Electrolyte‐Gated Transistors and Machine Learning

Small, EarlyView.
We developed an ultrasensitive and highly selective biosensor by integrating bio‐functionalized reduced graphene oxide (rGO) electrolyte‐gated transistors (EGTs) and machine learning (ML) to detect miRNAs (miR‐34a, miR‐34b, and miR‐34c) associated with cancer and neurological disorders.
Ana Vitória Ferreira Deleigo, Gabrielle Coelho Lelis, Maria Luisa Braunger, Stefano Casalini, Yasmin Watanabe, Gabriel Ravanhani Schleder, Wilson Tiago Fonseca, Rafael Furlan de Oliveira   +7 more
wiley   +1 more source

Structural and functional comparison of MIF ortholog from Plasmodium yoelii with MIF from its rodent host

, 2010
Host-derived macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infection, especially in malarial anemia. Although two Plasmodium parasite-derived MIF orthologs, Plasmodium falciparum MIF and P.
Yan-Feng Zhou, Lianhui Zhang, Shao, Dingding, Zhou, Yan-Feng, Yahui Lin, Han, Zhifu, Dingding Shao, Wang, Heng, Wang, Zhensheng, Xiang Zhong, Lin, Yahui, Bu, Lingyi, Xiao-Dong Su, Zhong, Xiang, Su, Xiao-Dong, Zhifu Han, Lingyi Bu, Zhang, Lianhui, Zhensheng Wang, Heng Wang   +19 more
core   +1 more source

Electrochemical and Biological Evaluation of Patterned TiO2@TiC‐Nanowires for Bio‐Interface Electrode

Small, EarlyView.
This study introduces a room‐temperature process to fabricate patterned TiO2@TiC core–shell nanowires, merging the biocompatibility of TiO2‐NWs with the high conductivity of TiC. Through sputtering pressure and time modulation, the nanowires morphology and electrochemical properties are tuned, enabling enhanced capacitance, stability, and guided ...
Roaa Sait, Shofarul Wustoni, Nabeel Aslam, Camelia Florica, Andrea Diaz‐Gaxiola, Valentina‐Elena Musteata, Mohammed K. Drad, Stephen Ghandour, Georgian Melinte, Yaping Zhang, Mohammed Nejib Hedhili, Ahad Ali Syed, Menouer Saidani, Shahryar Khattak, Imed Eddine‐Gallouzi, Sahika Inal, Hala Aljawhari   +16 more
wiley   +1 more source

Robotic Palpation for Spatiotemporal Arterial Pulse Quantification and Mapping Using Multilevel Microdome‐Based Soft Pressure Sensors

Small, EarlyView.
This study presents the development of multilevel pressure‐sensitive layers replicated from liquid‐metal‐based structures for optimizing soft pressure sensors in robotic palpation. This approach enhances sensitivity and range for subtle arterial displacement detection.
Seong‐Min Im, Jaehwan Jang, Byeong‐Sun Park, Jiwon Choi, Kyeong Taek Oh, Min‐gu Kim   +5 more
wiley   +1 more source