Results 51 to 60 of about 20,905 (195)

Identification of alpha1-oleate as a potent regulator of adipokine-dependent metabolism, in bladder cancer tissue

Cancer & Metabolism
Background Metabolic dysfunctions are associated with increased cancer morbidity and rapid tumor progression. The alpha1-oleate complex has been used successfully to treat bladder cancer in a placebo-controlled Phase II study.
Farhan Haq, Siddharth Chinchankar, Ines Ambite, Shahram Ahmadi, Hien Tran, Atefeh Nazari, Antonin Brisuda, Jaromir Hacek, Marek Babjuk, Catharina Svanborg   +9 more
doaj   +1 more source

Multiple barriers maintain species boundaries in sympatric brood‐site deceptive Gastrodia orchids

PLANTS, PEOPLE, PLANET, EarlyView.
Societal Impact Statement Gastrodia orchids are inconspicuous forest plants that lack chlorophyll and obtain carbon from fungi. Their dull‐colored, ground‐level flowers are often hidden among leaf litter, yet they rely on small flies for pollination.
Kenji Suetsugu, Akihiro Nishimura, Shun K. Hirota, Masahito T. Kimura   +3 more
wiley   +1 more source

MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways.

PLoS Genetics, 2012
Extracellular guidance cues steer axons towards their targets by eliciting morphological changes in the growth cone. A key part of this process is the asymmetric recruitment of the cytoplasmic scaffolding protein MIG-10 (lamellipodin).
Yan Xu, Christopher C Quinn
doaj   +1 more source

Strong differentiation between source and ex situ populations of rare plant species revealed by next‐generation sequencing

PLANTS, PEOPLE, PLANET, EarlyView.
Biodiversity is being lost rapidly worldwide due to factors such as climate change and habitat loss. To help safeguard plant populations, conservation strategies include seed banks and conservation cultures. However, it remains unclear how cultivation affects genetic variation compared with wild populations.
Maximilian Alexander Steurer, Ellen Gradl, Lena Winkler, Christoph Reisch   +3 more
wiley   +1 more source

Environmental Stressors Influence Spatial Complexity in a Fluvial Macrophyte meadow

Remote Sensing in Ecology and Conservation, EarlyView.
This research investigates the nonlinear relationships between environmental stressors and the fine‐scale spatial complexity of a fluvial macrophytes meadow. The use of multivariate spatial analysis allowed us to identify two major environmental gradients (nutrients and light) and two major complexity gradients (related to abundance and fragmentation).
Arthur de Grandpré, Christophe Kinnard, Andrea Bertolo   +2 more
wiley   +1 more source

Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6

Journal of Diabetes Research, 2016
Mitogen inducible gene-6 (Mig-6) is a feedback inhibitor of epidermal growth factor receptor (EGFR) signaling pathway. The liver-specific knockout mice of the Mig-6 gene (Mig-6d/d) showed hepatomegaly and increased hypercholesterolemia.
Byung Kil Park, Eun-Ah Lee, Hee-Youn Kim, Jun Choul Lee, Koon Soon Kim, Won Hoon Jeong, Ki Young Kim, Bon Jeong Ku, Sang Dal Rhee   +8 more
doaj   +1 more source

A Retinomorphic Graphene Transistor Implementing Direction‐ and Velocity‐Selective Computation for In‐Sensor Image Stabilization

Small, EarlyView.
A multi‐gated ion‐gel graphene transistor architecture emulates spatiotemporal dendritic filtering inspired by biological direction‐selective retinal circuits. Leveraging distributed resistance‐capacitive ionic relaxation delays under combined excitation‐inhibition pulse routines, the solid‐state device exhibits programmable direction‐selective index ...
Jun Ha Park, HoYeon Kim, Jinkyung Kim, Hyun Jae Jang, Jae Wook Kim, Jongkil Park, Seongsik Park, Inho Kim, Suyoun Lee, Gyu Weon Hwang, Byeong‐Kwon Ju, Kyeong‐Seok Lee   +11 more
wiley   +1 more source

Organ Length Control by an ADAMTS Extracellular Protease in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2016
MIG-17, a secreted protease of the ADAMTS family, acts in the directed migration of gonadal distal tip cells (DTCs) through regulation of the gonadal basement membrane in Caenorhabditis elegans.
Yukimasa Shibata, Yuri Kawakado, Noriyoshi Hori, Kota Tanaka, Ryo Inoue, Tomomi Takano, Yukihiko Kubota, Kiyoji Nishiwaki   +7 more
doaj   +1 more source

Detection and Inhalation Hazard Assessment of Wear Particles Arising From Abrasion of Market‐relevant Graphene Reinforced Composites

Small, EarlyView.
Abrasion of few‐layer graphene (FLG)–epoxy composites generated respirable particles in which FLG remained fully embedded, as confirmed by correlative HR‑TEM, Raman, and ToF‑SIMS analyses. Advanced lung cell models revealed no cytotoxic or inflammatory responses, and only high‑dose epoxy particles reduced mucociliary clearance.
Govind Gupta, Jimmy Vernaz, Antje Vennemann, Maike Stange, Asmus Meyer‐Plath, Servane Contal, Sarah Zehnder, Ziting Wang, Aline Chary, Stephanie Eitner, Philipp Mueller, Vera M. Kissling, Samuel Constant, Lucie Chupin, Daniel Breitenstein, Birgit Hagenhoff, Tommaso Serchi, Bernadett Boda, Martin Wiemann, Peter Wick, Tina Buerki‐Thurnherr   +20 more
wiley   +1 more source

Microstructure Characterization of Bending Effects in 304L Stainless Steel Cladded with Low‐Alloy Steel Weld

steel research international, EarlyView.
Prebending of 304L/Q345R cladded plates significantly alters the subsequent weld thermal cycle and modifies the local interfacial microstructure. Combined electron backscatter diffraction (EBSD) and microscopy analysis demonstrates that deformation twinning, martensitic transformation, and defect initiation are concentrated at the trimaterial junction,
Ali Fahem, Elsiddig Elmukashfi, Hong Dong   +2 more
wiley   +1 more source