Results 41 to 50 of about 124,603 (293)
Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova +5 more
wiley +1 more source
Frontiers in Neurology, 2017 IntroductionMigraine and depression frequently occur as comorbid conditions, and it has been hypothesized that migraine with and without depression may have a different genetic background.
Mate Magyar +25 more
doaj +1 more source
The Chronic Migraine Brain: What Have We Learned From Neuroimaging?
Frontiers in Neurology, 2020 Chronic migraine is a highly disabling disease with a great impact on socioeconomic functioning and quality of life of migraine patients. Chronic migraine usually evolves from episodic migraine that gradually increases in attack frequency, supporting the
Massimo Filippi +4 more
doaj +1 more source
Chronic Migraine Pathophysiology and Treatment: A Review of Current Perspectives
Frontiers in Pain Research, 2021 Chronic migraine is a disabling neurological disorder that imposes a considerable burden on individual and socioeconomic outcomes. Chronic migraine is defined as headaches occurring on at least 15 days per month with at least eight of these fulfilling ...
Tiffani J. Mungoven +2 more
doaj +1 more source
Pathophysiology of migraine [PDF]
Annals of Indian Academy of Neurology, 2006 Migraine is a common disabling brain disorder whose pathophysiology is now being better understood. The study of anatomy and physiology of pain producing structures in the cranium and the central nervous system modulation of the input have led to the conclusion that migraine involves alterations in the sub-cortical aminergic sensory modulatory systems ...
openaire +6 more sources
Arthritis Care &Research, EarlyView.As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox +3 more
wiley +1 more source
Scientific Reports, 2022 Altered periaqueductal gray matter (PAG) functional connectivity contributes to brain hyperexcitability in migraine. Although tryptophan modulates neurotransmission in PAG projections through its metabolic pathways, the effect of plasma tryptophan on PAG
Kinga Gecse +13 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho +7 more
wiley +1 more source
The Journal of Headache and Pain, 2019 Migraine is a major public health problem afflicting approximately 10% of the general population and is a leading cause of disability worldwide, yet our understanding of the basis mechanisms of migraine remains incomplete.
Jakob Møller Hansen, Andrew Charles
doaj +1 more source
Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice
Advanced Science, EarlyView.J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu +15 more
wiley +1 more source