Results 51 to 60 of about 243,193 (361)

Real-life use of onabotulinumtoxinA for symptom relief in patients with chronic migraine: REPOSE study methodology and baseline data

The Journal of Headache and Pain, 2017
Background Migraine is a debilitating neurological disorder that affects 14.1% of the US and 14.7% of the European populations. Chronic migraine (CM) is broadly defined as headache occurring on ≥15 days per month for ≥3 months, and has an estimated ...
Brendan Davies, Charly Gaul, Paolo Martelletti, Juan Carlos García-Moncó, Stephanie Brown   +4 more
doaj   +1 more source

Intravenous ketamine for subacute treatment of refractory chronic migraine: a case series. [PDF]

, 2016
BACKGROUND: Refractory migraine is a challenging condition with great impact on health related quality of life. Intravenous (IV) ketamine has been previously used to treat various refractory pain conditions.
Ashina, Sait, Lauritsen, Clinton, Lipton, Richard B., Mazuera, Santiago   +3 more
core   +3 more sources

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Trait Rumination Influences Neural Correlates of the Anticipation but Not the Consumption Phase of Reward Processing

Frontiers in Behavioral Neuroscience, 2017
Cumulative evidence suggests that trait rumination can be defined as an abstract information processing mode, which leads people to constantly anticipate the likely impact of present events on future events and experiences. A previous study with remitted
Natália Kocsel, Natália Kocsel, Natália Kocsel, Edina Szabó, Edina Szabó, Edina Szabó, Attila Galambos, Attila Galambos, Attila Galambos, Andrea Édes, Andrea Édes, Dorottya Pap, Rebecca Elliott, Rebecca Elliott, Lajos R. Kozák, György Bagdy, György Bagdy, Gabriella Juhász, Gabriella Juhász, Gabriella Juhász, Gyöngyi Kökönyei, Gyöngyi Kökönyei   +21 more
doaj   +1 more source

Rethinking Strategies for a Pharmaceutical Approach to Pain Related to Connective Tissue–Related Raynaud Phenomenon in the United States

Arthritis Care &Research, EarlyView.
Objective There are no US Food and Drug Administration–approved therapies for Raynaud phenomenon (RP) in the United States. Clinical trials have been challenged by study design. Important advances in RP patient‐reported outcome measures and mechanistic quantification allow RP‐related pain characterization.
Tracy M. Frech, Charles G. Frech, W. David Merryman, Andrew Sternlicht, Justin Baba   +4 more
wiley   +1 more source

Headache Phenotype and the Psychosocial Burden of Cluster Headaches: An Analysis of Patients Prior to Hospitalization

Pain and Therapy
Introduction The specific headache phenotype, accompanying symptoms and psychological impact that lead to admission of patients with cluster headache are not yet known.
Carl Hartmut Göbel, Britta Koch, Katja Heinze-Kuhn, Axel Heinze, Anna Cirkel, Hartmut Göbel   +5 more
doaj   +1 more source

Motor skills in children with primary headache: A pilot case-control study [PDF]

, 2018
Background: Headache is the most common painful manifestation in the developmental age, often accompanied by severe disability such as scholastic absenteeism, low quality of academic performance and compromised emotional functioning. The aim of the study
Cerroni F., Chisari M. G., D'Oro L., Di Folco A., Gallai B., Geraci D., Lavano F., Lavano S. M., Magliulo R. M., Marotta R., Marsala G., Murabito P., Parisi L., Picciocchi E., Polito A. N., Romano P., Russo D., Salerno M., Salerno M., Sorrentino M., Testa D., Tripi G.   +21 more
core   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study

BMC Neurology, 2019
Background The anterior cingulate cortex (ACC) is a key structure of the pain processing network. Several structural and functional alterations of this brain area have been found in migraine.
Andrea Edit Edes, Shane McKie, Edina Szabo, Gyongyi Kokonyei, Dorottya Pap, Terezia Zsombok, Mate Magyar, Eva Csepany, Gabor Hullam, Adam Gyorgy Szabo, Lajos Rudolf Kozak, Gyorgy Bagdy, Gabriella Juhasz   +12 more
doaj   +1 more source

Migraine: Diagnosis, treatment and understanding c1960-2010 [PDF]

, 2014
seminar transcriptThere are around eight million migraine sufferers in the UK today. This Witness Seminar looked at the last 50 years of research into the diagnosis and treatment of the condition and the changing attitudes of the medical profession ...
Overy, C, Tansey, EM
core