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Pathophysiology of migraine [PDF]
Annals of Indian Academy of Neurology, 2006 Migraine is a common disabling brain disorder whose pathophysiology is now being better understood. The study of anatomy and physiology of pain producing structures in the cranium and the central nervous system modulation of the input have led to the conclusion that migraine involves alterations in the sub-cortical aminergic sensory modulatory systems ...
openaire +6 more sources
Estimation of migraine prevalence considering active and inactive states across different age groups
The Journal of Headache and Pain, 2023 Background Migraine is a very common headache disorder on the population level, characterized by symptomatic attacks (activity). For many people with migraine, the migraine symptoms intermittently or permanently cease during their lifetime (inactive ...
Marco Piccininni +3 more
doaj +1 more source
The Journal of Headache and Pain, 2019 Background and aimMonoclonal antibodies acting on the calcitonin gene-related peptide or on its receptor are new drugs to prevent migraine. Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor ...
S. Sacco +6 more
semanticscholar +1 more source
Failure of feedback as a putative common mechanism of spreading depolarizations in migraine and stroke [PDF]
, 2008 The stability of cortical function depends critically on proper regulation. Under conditions of migraine and stroke a breakdown of transmembrane chemical gradients can spread through cortical tissue. A concomitant component of this emergent spatio-temporal pattern is a depolarization of cells detected as slow voltage variations.
arxiv +1 more source
Migraine prevalence, disease burden, and the need for preventive therapy
Neurology, 2007 Objectives: 1) To reassess the prevalence of migraine in the United States; 2) to assess patterns of migraine treatment in the population; and 3) to contrast current patterns of preventive treatment use with recommendations for use from an expert ...
R. Lipton +5 more
semanticscholar +1 more source
The Chronic Migraine Brain: What Have We Learned From Neuroimaging?
Frontiers in Neurology, 2020 Chronic migraine is a highly disabling disease with a great impact on socioeconomic functioning and quality of life of migraine patients. Chronic migraine usually evolves from episodic migraine that gradually increases in attack frequency, supporting the
Massimo Filippi +4 more
doaj +1 more source
Two-dimensional wave patterns of spreading depolarization: retracting, re-entrant, and stationary waves [PDF]
, 2009 We present spatio-temporal characteristics of spreading depolarizations (SD) in two experimental systems: retracting SD wave segments observed with intrinsic optical signals in chicken retina, and spontaneously occurring re-entrant SD waves that repeatedly spread across gyrencephalic feline cortex observed by laser speckle flowmetry.
arxiv +1 more source
Ubrogepant for the Treatment of Migraine.
New England Journal of Medicine, 2019 BACKGROUND Ubrogepant is an oral, small-molecule calcitonin gene-related peptide receptor antagonist for acute migraine treatment. METHODS We conducted a randomized trial to evaluate the efficacy, safety, and side-effect profile of ubrogepant.
D. Dodick +6 more
semanticscholar +1 more source
The Journal of Headache and PainBackground Migraine is the most common complex neurological disorder, affecting over a billion people worldwide. Neurogenic inflammation has long been recognized as a key factor in the pathophysiology of migraine though little research has been directed ...
Tissa Wijeratne +8 more
doaj +1 more source
The Journal of Headache and Pain, 2021 Background Galcanezumab, a humanized monoclonal antibody that binds calcitonin gene-related peptide, has demonstrated a significant reduction in monthly migraine headache days compared with placebo. Here, we analyze data from 3 randomized clinical trials
Michael Ament +6 more
doaj +1 more source