Results 91 to 100 of about 18,934 (225)

Cerebrospinal Fluid and Plasma Concentrations of Atogepant in Humans

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT The aim of this study was to determine the cerebrospinal fluid (CSF) to plasma concentration ratio of atogepant. Healthy adult participants (N = 28) were enrolled into this phase 1, open‐label study and received atogepant 60 mg once daily for 8 days. Steady‐state atogepant concentrations were determined from CSF samples collected on Day 6 at 2
Ramesh R. Boinpally, Joel M. Trugman
wiley   +1 more source

Efficacy, IHS Guideline Adherence, and Methodological Quality of Noninvasive Neuromodulation Clinical Trials in Migraine and Cluster Headache: A Systematic Review

European Journal of Neurology, Volume 33, Issue 6, June 2026.
ABSTRACT Background Noninvasive neuromodulation has emerged as a promising approach for acute and preventive treatment of migraine and cluster headache. This systematic review evaluates how noninvasive neuromodulation trials align with guidelines by the International Headache Society (IHS), their efficacy on IHS‐recommended outcomes, and the robustness
Javiera Canales‐Rodríguez, Cornelius Angerhöfer, Edoardo Caronna, Bianca Raffaelli, Lucas Hendrik Overeem, Patricia Pozo‐Rosich, Uwe Reuter   +6 more
wiley   +1 more source

Effectiveness and acceptability of oral migraine preventives: A prospective, observational study

Headache: The Journal of Head and Face Pain, Volume 66, Issue 6, Page 1250-1262, June 2026.
Plain Language Summary Most knowledge about migraine preventive medicines comes from clinical trials, but less is known about their real‐world outcomes and side effects. We followed 254 people with migraine who started on commonly used oral migraine preventive drugs and tracked their results over 12 weeks.
Hedda S. Riise, Melanie R. Simpson, Ketil A. Espnes, Erling A. Tronvik, Andreas K. Husøy, Lise R. Øie, Anker Stubberud, Emil Kofoed, Aurora H. Alstad, Hedda H. Hagen, Maren G. Lien, Marie L. Stavseng, Ella R. Sæther, Tore Wergeland   +13 more
wiley   +1 more source

Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology

, 2009
Migraine pathophysiology is thought to involve activation of the trigeminal fibres which innervate dural structures. The nociceptive inflow from the meninges is relayed to the trigeminocervical complex (TCC), before ascending to higher brain areas ...
Andreou, A.
core  

(REM) sleep intrusions in migraine patients, independent of migraine aura

, 2023
Background and purposeMigraine aura, near-death experiences (NDEs), and rapid eye movement (REM) sleep intrusions might share common mechanisms. Here, we investigated the prevalence of NDEs and REM sleep intrusions in people with migraine.
Maureen Steinicke, Triller, Paul, Paul Triller, Kristin S. Lange, Dreier, Jens P., Reuter, Uwe, Jasper Mecklenburg, Overeem, Lucas H., Lucas H. Overeem, Steinicke, Maureen, Daniel Kondziella, Fitzek, Mira P., Lange, Kristin S., Mira P. Fitzek, Neeb, Lars, Jens P. Dreier, Bianca Raffaelli, Lars Neeb, Siebert, Anke, Raffaelli, Bianca, Kull, Pia, Mecklenburg, Jasper, Kondziella, Daniel, Pia Kull, Anke Siebert, Uwe Reuter   +25 more
core   +1 more source

Utility of ANA in hospitalized patients with headache and suspected systemic autoimmune disease

Headache: The Journal of Head and Face Pain, Volume 66, Issue 6, Page 1244-1249, June 2026.
Abstract Objective This study evaluates antinuclear antibody (ANA) test performance in identifying rheumatologic conditions as the source of the headache. Background ANA testing is widely used to screen for autoimmune diseases in patients with headaches, but its diagnostic utility remains unclear. Methods In this retrospective analytic, cross‐sectional
Erez Magiel, Melanie Shanie Roitman, Barak Pflantzer, Roni Loebenstein Dagan, Roni Sharon, Abdualla Watad, Nicola Maggio, Saar Anis   +7 more
wiley   +1 more source

Intravenous Endothelin-1 Infusion Does Not Induce Aura or Headache in Migraine Patients With Aura

, 2020
Objective: To investigate whether intravenously infused provokes migraine aura and migraine headache in migraine patients with aura. Background: Migraine with aura has been associated with endothelial dysfunction and increased stroke risk. The initiating
Afrim Iljazi, Sugimoto, Kazutaka, Hougaard, Anders, Ashina, Messoud, Iljazi, Afrim, Ayata, Cenk, Kazutaka Sugimoto, Messoud Ashina, Samaira Younis, Cenk Ayata, Younis, Samaira, Anders Hougaard   +11 more
core   +1 more source

A cause for concern? How discrepancies between self‐ and parent proxy–reported quality of life are associated to well‐being in children and adolescents attending a headache outpatient clinic: A case‐control study

Headache: The Journal of Head and Face Pain, Volume 66, Issue 6, Page 1275-1293, June 2026.
Abstract Objectives We examined whether discrepancies between self‐reported and parent proxy–reported health‐related quality of life (HRQoL) were associated with child well‐being in children and adolescents attending a headache clinic compared to controls.
Amalie Akulenok Berring‐Uldum, Maria J. Miranda, Nanette Marinette Monique Debes   +2 more
wiley   +1 more source

Pharmacological management of migraine

, 2019
Migraine is one of the most common, disabling neurological disorder characterized by multiple phases: premonitory, aura, and headache. Understanding of the pathophysiology of each phase of migraine has developed over recent years.
Kwon, Yesul
core  

Conventional cigarettes, novel heated tobacco products, and self‐reported frequent headache association in Japanese individuals: Insights from the JASTIS study, a Japanese cross‐sectional analysis

Headache: The Journal of Head and Face Pain, Volume 66, Issue 6, Page 1317-1329, June 2026.
Plain Language Summary Headache is a common health problem, and tobacco products, such as conventional cigarettes and heated tobacco products (HTPs), may be associated with it. Using data from over 23,000 adults in the Japan Society and New Tobacco Internet Survey, we examined the relationships between cigarette and HTP use and self‐reported frequent ...
Masahito Katsuki, Kieran Moran, Muneto Tatsumoto, Keisuke Suzuki, Tomokazu Shimazu, Yasuhiko Matsumori, Yutaro Fuse, Miguel Á. Huerta, Daijiro Sugiyama, Jackson T. S. Cheung, Siobhán O'Connor, Tomás Ward, Takahiro Tabuchi   +12 more
wiley   +1 more source